Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.41 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.40 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.40 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.40 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.40 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21045659 | 0.84 | TRPC6 (0.48) | TRPC6LMNATSHRMAPK1HPGD | |
| SCHEMBL21045701 | 0.83 | TSHR (0.55) | TRPC6TSHRMAPK1HPGDL3MBTL1 | |
| SCHEMBL22367073 | 0.73 | NPSR1 (0.47) | TRPC6TSHRMAPK1HPGDNCOA1 | |
| SCHEMBL20116607 | 0.73 | NPSR1 (0.47) | TRPC6TSHRMAPK1HPGDNCOA1 | |
| SCHEMBL21045649 | 0.73 | TRPC6 (0.50) | TRPC6MAPK1HPGDL3MBTL1MAPT | |
| SCHEMBL29040318 | 0.72 | HDAC1 (0.48) | LMNATSHRHDAC1HDAC2MAPK1 | |
| SCHEMBL29040335 | 0.72 | MAPK8 (0.44) | LMNATSHRHDAC1HDAC2MAPK1 | |
| SCHEMBL18031339 | 0.71 | TRPC6 (0.51) | TRPC6TSHRHPGDL3MBTL1MAPT | |
| SCHEMBL5808328 | 0.70 | SMPD1 (0.52) | TRPC6HDAC1HDAC6HDAC8HPGD | |
| SCHEMBL21761472 | 0.70 | TRPC6 (0.42) | TRPC6TSHRMAPK1HPGDL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117777121-A | Compounds and uses thereof | 詹森药业有限公司 | 2024-03-29 | — | — | CN | disclosed |
| CN-110099898-B | Compounds and uses thereof | 优曼尼蒂治疗公司 | 2023-07-25 | — | — | CN | disclosed |