Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5620745 | 0.77 | PARP1 (0.74) | PARP1 | |
| SCHEMBL5620426 | 0.76 | PARP1 (0.68) | PARP1 | |
| SCHEMBL5621000 | 0.75 | PARP1 (0.68) | PARP1 | |
| SCHEMBL631198 | 0.75 | PARP1 (1.00) | PARP1PARP2 | |
| SCHEMBL630294 | 0.75 | PARP1 (1.00) | PARP1PARP2 | |
| SCHEMBL5621808 | 0.75 | PARP1 (0.72) | PARP1PARP2 | |
| SCHEMBL5621895 | 0.75 | PARP1 (0.71) | PARP1 | |
| SCHEMBL5620966 | 0.74 | PARP1 (0.69) | PARP1PARP2 | |
| SCHEMBL5621907 | 0.74 | PARP1 (0.66) | PARP1 | |
| SCHEMBL5620195 | 0.74 | PARP1 (0.65) | PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9580410-B2 | 2-((R)-2-methylpyrrolidin-2-yl)-1H-benzimidazole-4-carboxamide crystalline form 1 | ABBVIE INC. (US) | 2017-02-28 | — | — | US | disclosed |
| EP-2722046-B1 | 2-((R)-2-methylpyrrolidin-2-yl)-1H-benzimidazole-4-carboxamide crystalline form 1 | ABBVIE IRELAND UNLIMITED CO (IE) | 2016-12-21 | — | — | EP | disclosed |
| US-20150148392-A1 | 2-((R)-2-METHYLPYRROLIDIN-2-YL)-1H-BENZIMIDAZOLE-4-CARBOXAMIDE CRYSTALLINE FORM 1 | ABBVIE INC. | 2015-05-28 | — | — | US | disclosed |
| US-8835647-B2 | 2-((R)-2-methylpyrrolidin-2-yl)-1H-benzimidazole-4-carboxamide crystalline form 1 | ABBVIE INC. (US) | 2014-09-16 | — | — | US | disclosed |
| EP-2722046-A1 | 2-((R)-2-methylpyrrolidin-2-YL)-1H-benzimidazole-4-carboxamide crystalline form 1 | AbbVie Bahamas Ltd. (BS) | 2014-04-23 | — | — | EP | disclosed |
| US-20140024838-A1 | 2-((R)-2-METHYLPYRROLIDIN-2-YL)-1H-BENZIMIDAZOLE-4-CARBOXAMIDE CRYSTALLINE FORM 1 | ABBVIE INC. (US) | 2014-01-23 | — | — | US | disclosed |
| US-20130123317-A1 | 2-((R)-2-METHYLPYRROLIDIN-2-YL)-1H-BENZIMIDAZOLE-4-CARBOXAMIDE CRYSTALLINE FORM 1 | ABBVIE INC. (US) | 2013-05-16 | — | — | US | disclosed |
| US-8372987-B2 | Title compound is Veliparib, a Poly(ADP-ribose) polymerase i.e. PARP inhibitor; anticancer agent | ABBVIE INC. (US) | 2013-02-12 | — | — | US | disclosed |
| EP-2212327-A1 | 2-((R)-2-METHYLPYRROLIDIN-2-YL)-1H-BENZIMIDAZOLE-4-CARBOXAMIDE CRYSTALLINE FORM 1 | Abbott Laboratories (US) | 2010-08-04 | — | — | EP | disclosed |
| US-20090099245-A1 | 2-{(R)-2-METHYLPYRROLIDIN-2-YL)-1H-BENZIMIDAZOLE-4-CARBOXAMIDE CRYSTALLINE FORM 1 | ABBOTT LABORATORIES (US) | 2009-04-16 | — | — | US | disclosed |
| WO-2009049111-A1 | 2-((R)-2-METHYLPYRROLIDIN-2-YL)-1H-BENZIMIDAZOLE-4-CARBOXAMIDE CRYSTALLINE FORM 1 | ABBOTT LABORATORIES (US) | 2009-04-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140024838-A1 | 2-((R)-2-METHYLPYRROLIDIN-2-YL)-1H-BENZIMIDAZOLE-4-CARBOXAMIDE CRYSTALLINE FORM 1 | TPMT, UACA, GOT2 | PARP1 757/4885PARP2 260/4885 |
| US-20090099245-A1 | 2-{(R)-2-METHYLPYRROLIDIN-2-YL)-1H-BENZIMIDAZOLE-4-CARBOXAMIDE CRYSTALLINE FORM 1 | TPMT, MALT1, GOT2 | PARP1 739/4885PARP2 266/4885 |
| US-20150148392-A1 | 2-((R)-2-METHYLPYRROLIDIN-2-YL)-1H-BENZIMIDAZOLE-4-CARBOXAMIDE CRYSTALLINE FORM 1 | TPMT, UACA, GOT2 | PARP1 757/4885PARP2 260/4885 |
| US-20130123317-A1 | 2-((R)-2-METHYLPYRROLIDIN-2-YL)-1H-BENZIMIDAZOLE-4-CARBOXAMIDE CRYSTALLINE FORM 1 | TPMT, UACA, GOT2 | PARP1 757/4885PARP2 260/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.