Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK11 | Q15759 | 15/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 15/20 | 0.52 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.45 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL243053 | 0.92 | MAPK11 (0.52) | MAPK11MAPK14MAPK13MAPK12NPC1 | |
| SCHEMBL2902012 | 0.90 | LMNA (0.54) | MAPK11MAPK14NPC1HSP90AA1RAB9A | |
| SCHEMBL239890 | 0.85 | BRD4 (0.61) | MAPK11MAPK14MAPK13MAPK12BRD4 | |
| SCHEMBL239703 | 0.82 | NPC1 (0.56) | MAPK11MAPK14NPC1HSP90AA1RAB9A | |
| SCHEMBL243632 | 0.79 | MAPK11 (0.50) | MAPK11MAPK14MAPK13MAPK12 | |
| SCHEMBL243394 | 0.79 | MAPK14 (0.58) | MAPK11MAPK14 | |
| SCHEMBL242779 | 0.78 | KMT2A (0.55) | MAPK11MAPK14LMNATSHR | |
| SCHEMBL243655 | 0.78 | MAPK14 (0.51) | MAPK11MAPK14MAPK13MAPK12 | |
| SCHEMBL2901219 | 0.77 | MAPK14 (0.52) | MAPK11MAPK14MAPK13MAPK12 | |
| SCHEMBL244250 | 0.77 | MAPK14 (0.52) | MAPK11MAPK14MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1699766-B1 | AMIDE DERIVATIVES BEARING A CYCLOPROPYLAMINOACARBONYL SUBSTITUENT USEFUL AS CYTOKINE INHIBITORS | ASTRAZENECA AB (SE) | 2010-08-11 | — | — | EP | claimed |
| EP-1699766-A1 | AMIDE DERIVATIVES BEARING A CYCLOPROPYLAMINOACARBONYL SUBSTITUENT USEFUL AS CYTOKINE INHIBITORS | AstraZeneca AB (SE) | 2006-09-13 | — | — | EP | disclosed |
| WO-2005061465-A1 | AMIDE DERIVATIVES BEARING A CYCLOPROPYLAMINOACARBONYL SUBSTITUENT USEFUL AS CYTO KINE INHIBITORS | ASTRAZENECA AB (SE) | 2005-07-07 | — | — | WO | disclosed |