Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.61 |
| ▸ | GLS | O94925 | 8/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | ESRRA | P11474 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29047532 | 0.81 | KMT2A (0.70) | GLSKMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL15727691 | 0.75 | GLS (0.78) | GLS | |
| SCHEMBL29047592 | 0.75 | GLS (0.60) | GLSKMT2AMEN1ALDH1A1CYP1A2 | |
| SCHEMBL29047549 | 0.74 | RXFP1 (0.58) | SIRT2GLSKMT2AMEN1ALDH1A1 | |
| SCHEMBL29047587 | 0.74 | L3MBTL1 (0.60) | SIRT2KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL29047579 | 0.74 | POLB (0.61) | GLSKMT2AMEN1ALDH1A1CYP1A2 | |
| SCHEMBL21443479 | 0.73 | GLS (0.70) | GLS | |
| SCHEMBL6374673 | 0.72 | KAT8 (0.60) | GLSKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL1279155 | 0.71 | USP30 (0.61) | KMT2AMEN1KDM4EALDH1A1MAPT | |
| SCHEMBL29047569 | 0.71 | TP53 (0.73) | GLSKMT2AMEN1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108947931-B | Thiazole amide compound, preparation method thereof, pharmaceutical composition and application | 中国科学院上海有机化学研究所 | 2023-07-07 | — | — | CN | disclosed |