Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 11/20 | 0.54 |
| ▸ | JAK1 | P23458 | 11/20 | 0.54 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.44 |
| ▸ | F13A1 | P00488 | 1/20 | 0.43 |
| ▸ | TGM2 | P21980 | 1/20 | 0.43 |
| ▸ | TGM1 | P22735 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29048015 | 0.91 | JAK2 (0.46) | JAK2JAK1GPR119F13A1TGM2 | |
| SCHEMBL25248842 | 0.86 | CYP2D6 (0.49) | JAK2JAK1GPR119ALDH1A1 | |
| SCHEMBL222683 | 0.84 | GPR119 (0.49) | JAK2JAK1GPR119ALDH1A1MEN1 | |
| SCHEMBL17140944 | 0.84 | JAK2 (0.49) | JAK2JAK1MEN1KMT2A | |
| SCHEMBL761108 | 0.83 | PTPN2 (0.43) | JAK2JAK1GPR119ALDH1A1MAPT | |
| SCHEMBL17140737 | 0.83 | JAK2 (0.52) | JAK2JAK1GPR119ALDH1A1PTPN2 | |
| SCHEMBL17140650 | 0.83 | JAK2 (0.50) | JAK2JAK1GPR119 | |
| SCHEMBL17140954 | 0.82 | ALDH1A1 (0.57) | JAK2JAK1GPR119ALDH1A1KMT2A | |
| SCHEMBL17140574 | 0.81 | JAK2 (0.53) | JAK2JAK1ALDH1A1MAPTRAB9A | |
| SCHEMBL30494560 | 0.81 | F13A1 (0.42) | JAK2JAK1GPR119F13A1TGM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4196478-A1 | HETEROARYL SUBSTITUTED SPIROPIPERIDINYL DERIVATIVES AND PHARMACEUTICAL USES THEREOF | Novartis AG (CH) | 2023-06-21 | — | — | EP | disclosed |
| CN-116157404-A | Heteroaryl substituted spiropiperidinyl derivatives and pharmaceutical uses thereof | 诺华股份有限公司 | 2023-05-23 | — | — | CN | disclosed |