Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | RXRA | P19793 | 3/20 | 0.31 |
| ▸ | RXRB | P28702 | 3/20 | 0.31 |
| ▸ | RXRG | P48443 | 3/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | CCNC | P24863 | 1/20 | 0.30 |
| ▸ | CDK8 | P49336 | 1/20 | 0.30 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9426950 | 0.78 | MEN1 (0.48) | KMT2AMEN1LMNAS1PR2MAPT | |
| SCHEMBL31546887 | 0.78 | HSP90AA1 (0.40) | KMT2AMEN1MAPTPOLBALDH1A1 | |
| SCHEMBL21634791 | 0.76 | CCNC (0.36) | KMT2AMEN1LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL6628690 | 0.74 | KMT2A (0.51) | KMT2AMEN1LMNAMAPTPOLB | |
| SCHEMBL28989535 | 0.74 | KMT2A (0.38) | KMT2AS1PR2MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL31530948 | 0.71 | POLB (0.43) | KMT2AMEN1LMNAMAPTPOLB | |
| SCHEMBL8109431 | 0.71 | LMNA (0.50) | LMNAPOLBALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL2854934 | 0.70 | LMNA (0.48) | LMNAS1PR2POLBALDH1A1SMN1; SMN2 | |
| SCHEMBL25212309 | 0.70 | KEAP1 (0.36) | KMT2AMEN1LMNAS1PR2MAPT | |
| SCHEMBL28643764 | 0.69 | HSD17B10 (0.42) | KMT2AMEN1KDM4ECDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116157404-A | Heteroaryl substituted spiropiperidinyl derivatives and pharmaceutical uses thereof | 诺华股份有限公司 | 2023-05-23 | — | — | CN | disclosed |