Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDRD2HTR1BHTR1DHTR1F
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | TET2 | Q6N021 | 6/20 | 0.39 |
| ▸ | TET3 | O43151 | 2/20 | 0.39 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.39 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.37 |
| ▸ | KDM4A | O75164 | 2/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.37 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.37 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.36 |
| ▸ | KMO | O15229 | 1/20 | 0.33 |
| ▸ | PGK1 | P00558 | 1/20 | 0.32 |
| ▸ | PGK2 | P07205 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL11130777 | 0.84 | SMN1; SMN2 (0.79) | SMN1; SMN2TDP1TET2TET3TET1 | |
| Malic Acid SCHEMBL27351502 | 0.82 | SMN1; SMN2 (0.75) | SMN1; SMN2TDP1TET2TET3TET1 | |
| Malic Acid SCHEMBL27351503 | 0.82 | SMN1; SMN2 (0.75) | SMN1; SMN2TDP1TET2TET3TET1 | |
| Malic Acid SCHEMBL20523331 | 0.82 | SMN1; SMN2 (0.75) | SMN1; SMN2TDP1TET2TET3TET1 | |
| Malic Acid SCHEMBL27393374 | 0.82 | SMN1; SMN2 (0.75) | SMN1; SMN2TDP1TET2TET3TET1 | |
| Malic Acid SCHEMBL20366118 | 0.82 | SMN1; SMN2 (0.94) | SMN1; SMN2TDP1TET2TET3TET1 | |
| Malic Acid SCHEMBL631100 | 0.82 | SMN1; SMN2 (0.94) | SMN1; SMN2TDP1TET2TET3TET1 | |
| Malic Acid SCHEMBL20366119 | 0.82 | SMN1; SMN2 (0.94) | SMN1; SMN2TDP1TET2TET3TET1 | |
| Malic Acid SCHEMBL631099 | 0.82 | SMN1; SMN2 (0.94) | SMN1; SMN2TDP1TET2TET3TET1 | |
| Malic Acid SCHEMBL3499977 | 0.80 | SMN1; SMN2 (0.71) | SMN1; SMN2TDP1TET2TET3TET1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115181332-B | Preparation and application of bi-component core-shell structure particle BT@PANI-ferroferric oxide | 兰州理工大学 | 2023-08-11 | — | — | CN | claimed |