Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 7/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.68 |
| ▸ | NSD2 | O96028 | 3/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | APEX1 | P27695 | 1/20 | 0.57 |
| ▸ | METAP2 | P50579 | 1/20 | 0.56 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.56 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.56 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.56 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.54 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.52 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2236766 | 0.94 | HPGD (0.77) | HPGDKDM4EALDH1A1NSD2HSD17B10 | |
| SCHEMBL1060622 | 0.83 | HPGD (0.71) | HPGDKDM4EALDH1A1NSD2HSD17B10 | |
| SCHEMBL6038030 | 0.81 | HPGD (0.73) | HPGDKDM4EALDH1A1NSD2HSD17B10 | |
| SCHEMBL28728994 | 0.81 | HPGD (0.73) | HPGDKDM4EALDH1A1NSD2HSD17B10 | |
| SCHEMBL14727423 | 0.81 | ALDH1A1 (0.73) | HPGDKDM4EALDH1A1NSD2HSD17B10 | |
| SCHEMBL28901311 | 0.81 | ALDH1A1 (0.73) | HPGDKDM4EALDH1A1NSD2HSD17B10 | |
| SCHEMBL29433995 | 0.81 | HPGD (1.00) | HPGDKDM4EALDH1A1NSD2HSD17B10 | |
| SCHEMBL28730014 | 0.81 | HPGD (1.00) | HPGDKDM4EALDH1A1NSD2HSD17B10 | |
| SCHEMBL4478849 | 0.81 | NSD2 (1.00) | HPGDKDM4EALDH1A1NSD2HSD17B10 | |
| SCHEMBL31680569 | 0.81 | KMT2A (0.89) | HPGDNSD2KMT2AUSP2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116354855-B | Preparation method of cilansetrot sodium | 江苏百奥信康医药科技有限公司 | 2024-02-02 | — | — | CN | disclosed |
| CN-116354855-A | Preparation method of cilansetrot sodium | 江苏百奥信康医药科技有限公司 | 2023-06-30 | — | — | CN | disclosed |