Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
| ▸ | KDM4A | O75164 | 1/20 | 0.35 |
| ▸ | KDM4B | O94953 | 1/20 | 0.35 |
| ▸ | KDM5C | P41229 | 1/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 3/20 | 0.34 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MITF | O75030 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30525564 | 1.00 | HDAC3 (0.36) | HDAC3HDAC1HDAC6KDM4AKDM4B | |
| SCHEMBL30525591 | 0.82 | KDM4A (0.44) | KDM4AKDM4BKDM5CKDM5BSYK | |
| SCHEMBL29049425 | 0.82 | KDM4A (0.44) | KDM4AKDM4BKDM5CKDM5BSYK | |
| SCHEMBL3405496 | 0.76 | EGLN1 (0.63) | HDAC3HDAC1HDAC6EGLN1MEN1 | |
| SCHEMBL30525586 | 0.76 | HDAC1 (0.41) | HDAC1HDAC6KDM4EP2RX7 | |
| SCHEMBL29049475 | 0.76 | HDAC1 (0.41) | HDAC1HDAC6KDM4EP2RX7 | |
| SCHEMBL29049509 | 0.75 | HPGDS (0.48) | KDM4EGAAMAPTMEN1MITF | |
| SCHEMBL30525571 | 0.75 | HPGDS (0.48) | KDM4EGAAMAPTMEN1MITF | |
| SCHEMBL30525576 | 0.75 | P2RX7 (0.46) | EGLN1KDM4EGAAMAPTMEN1 | |
| SCHEMBL29049458 | 0.75 | P2RX7 (0.46) | EGLN1KDM4EGAAMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116514769-B | 4-hydroxy pyrimidine-5-formylhydrazone derivative, preparation method, pharmaceutical composition and application | 中国药科大学 | 2024-02-27 | — | — | CN | disclosed |
| CN-116514769-A | 4-hydroxy pyrimidine-5-formylhydrazone derivative, preparation method, pharmaceutical composition and application | 中国药科大学 | 2023-08-01 | — | — | CN | disclosed |