Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 3/20 | 0.44 |
| ▸ | MMP13 | P45452 | 3/20 | 0.44 |
| ▸ | MMP2 | P08253 | 2/20 | 0.44 |
| ▸ | MMP9 | P14780 | 2/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1807247 | 0.84 | MMP13 (0.60) | MMP1MMP13MMP2MMP9CNR2 | |
| SCHEMBL9014097 | 0.83 | DPP4 (0.40) | MMP1MMP13MMP2MMP9HTR2B | |
| Hydrochloric Acid SCHEMBL29677688 | 0.83 | MMP13 (0.59) | MMP1MMP13MMP2MMP9CNR2 | |
| SCHEMBL9385647 | 0.80 | HTR2B (0.44) | MMP1MMP13MMP2MMP9HTR2B | |
| SCHEMBL22763324 | 0.80 | CNR2 (0.46) | MMP1MMP13MMP2MMP9CNR2 | |
| SCHEMBL2642449 | 0.78 | HTR2B (0.45) | MMP1MMP13MMP2MMP9HTR2B | |
| SCHEMBL27880690 | 0.78 | CYP2C19 (0.51) | MMP1MMP13MMP2MMP9HTR2B | |
| SCHEMBL1810844 | 0.78 | RAB9A (0.57) | MMP1MMP13CYP2C19RAB9AALDH1A1 | |
| SCHEMBL30358512 | 0.77 | HTR2B (0.41) | MMP1MMP13MMP2MMP9HTR2B | |
| SCHEMBL14207214 | 0.77 | DPP4 (0.42) | MMP1MMP13MMP2MMP9HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4263546-A1 | DIHYDROFUROPYRIDINE DERIVATIVES AS RHO- KINASE INHIBITORS | Chiesi Farmaceutici S.p.A. (IT) | 2023-10-25 | — | — | EP | disclosed |
| CN-116568303-A | Dihydrofuranopyridine derivatives as RHO-kinase inhibitors | 奇斯药制品公司 | 2023-08-08 | — | — | CN | disclosed |
| WO-2022128851-A1 | DIHYDROFUROPYRIDINE DERIVATIVES AS RHO- KINASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2022-06-23 | — | — | WO | disclosed |