Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.41 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.41 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.39 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.39 |
| ▸ | XIAP | P98170 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2902241 | 0.79 | HTR2C (0.49) | HTR2CSMN1; SMN2NPC1RAB9ACACNA1G | |
| SCHEMBL23124027 | 0.74 | HTR2C (0.46) | HTR2CSMN1; SMN2NPC1RAB9ACACNA1G | |
| SCHEMBL4058433 | 0.74 | ALDH1A1 (0.50) | HTR2CSMN1; SMN2NPC1RAB9AGAA | |
| SCHEMBL2787453 | 0.74 | HTR2C (0.58) | HTR2CSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL13490134 | 0.74 | HTR2C (0.58) | HTR2CSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL2579734 | 0.74 | HTR2C (0.58) | HTR2CSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL10797345 | 0.73 | ALDH1A1 (0.53) | HTR2CSMN1; SMN2NPC1RAB9AGAA | |
| SCHEMBL4336814 | 0.73 | HTR2C (0.51) | HTR2CSMN1; SMN2NPC1RAB9AGAA | |
| SCHEMBL20146330 | 0.73 | HTR2C (0.48) | HTR2CSMN1; SMN2NPC1RAB9ATSHR | |
| SCHEMBL27193408 | 0.73 | HTR2C (0.51) | HTR2CSMN1; SMN2NPC1RAB9ACACNA1G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2217226-A1 | PEPTIDE DEFORMYLASE INHIBITORS | GlaxoSmithKline LLC (US) | 2010-08-18 | — | — | EP | disclosed |
| WO-2009061879-A1 | PEPTIDE DEFORMYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-05-14 | — | — | WO | disclosed |