Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL4010790 | 0.98 | LMNA (0.50) | LMNASIGMAR1HRH3MAPTALDH1A1 | |
| SCHEMBL2905469 | 0.98 | SIGMAR1 (0.51) | LMNASIGMAR1HRH3MAPT | |
| Iodide SCHEMBL4008478 | 0.96 | SIGMAR1 (0.50) | LMNASIGMAR1HRH3MAPT | |
| SCHEMBL10594659 | 0.91 | SIGMAR1 (0.43) | LMNASIGMAR1HRH3 | |
| SCHEMBL9290957 | 0.89 | LMNA (0.66) | LMNASIGMAR1HRH3MAPTALDH1A1 | |
| SCHEMBL9290790 | 0.89 | LMNA (0.66) | LMNASIGMAR1HRH3MAPTALDH1A1 | |
| SCHEMBL9290890 | 0.89 | LMNA (0.66) | LMNASIGMAR1HRH3MAPTALDH1A1 | |
| Bromide SCHEMBL10340648 | 0.89 | SIGMAR1 (0.43) | LMNASIGMAR1HRH3 | |
| SCHEMBL9290829 | 0.87 | LMNA (0.62) | LMNASIGMAR1HRH3MAPTALDH1A1 | |
| SCHEMBL5924357 | 0.84 | SIGMAR1 (0.40) | LMNASIGMAR1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874761-B1 | 4H-1,2,4-TRIAZIN-5-ONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTORS | AVENTIS PHARMA SA (FR) | 2010-08-18 | — | — | EP | disclosed |