Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 2/20 | 0.40 |
| ▸ | CRACR2A | Q9BSW2 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KCNJ6 | P48051 | 3/20 | 0.38 |
| ▸ | KCNJ5 | P48544 | 3/20 | 0.38 |
| ▸ | KCNJ3 | P48549 | 3/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29780988 | 1.00 | MAPT (0.41) | MAPTPPARACRACR2APOLBKCNJ6 | |
| SCHEMBL29052152 | 0.86 | NPSR1 (0.40) | MAPTCRACR2AKCNJ6KCNJ5KCNJ3 | |
| SCHEMBL29780914 | 0.86 | NPSR1 (0.40) | MAPTCRACR2AKCNJ6KCNJ5KCNJ3 | |
| SCHEMBL29052238 | 0.83 | PPARA (0.53) | PPARACRACR2APOLBKCNJ6KCNJ5 | |
| SCHEMBL29052540 | 0.78 | MAPT (0.43) | MAPTPPARACCNA2CDK2CDK5 | |
| SCHEMBL29781023 | 0.78 | MAPT (0.43) | MAPTPPARACCNA2CDK2CDK5 | |
| SCHEMBL19377699 | 0.76 | KEAP1 (0.52) | CRACR2APOLBKCNJ6KCNJ5KCNJ3 | |
| SCHEMBL21777246 | 0.73 | KCNJ6 (0.45) | PPARACRACR2APOLBKCNJ6KCNJ5 | |
| SCHEMBL1671377 | 0.70 | CRACR2A (0.55) | CRACR2ALMNA | |
| SCHEMBL29052610 | 0.69 | PPARA (0.45) | PPARACRACR2AKCNJ6KCNJ5KCNJ3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116583287-A | Pyridazinone heterocyclic compound, preparation method and application thereof | 四川科伦博泰生物医药股份有限公司 | 2023-08-11 | — | — | CN | disclosed |