Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 3/20 | 0.53 |
| ▸ | KCNJ6 | P48051 | 4/20 | 0.47 |
| ▸ | KCNJ5 | P48544 | 4/20 | 0.47 |
| ▸ | KCNJ3 | P48549 | 4/20 | 0.47 |
| ▸ | RPA1 | P27694 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CRACR2A | Q9BSW2 | 4/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.40 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19377699 | 0.88 | KEAP1 (0.52) | KCNJ6KCNJ5KCNJ3SMN1; SMN2CRACR2A | |
| SCHEMBL21777246 | 0.87 | KCNJ6 (0.45) | PPARAKCNJ6KCNJ5KCNJ3SMN1; SMN2 | |
| SCHEMBL29052610 | 0.85 | PPARA (0.45) | PPARAKCNJ6KCNJ5KCNJ3SMN1; SMN2 | |
| SCHEMBL29052162 | 0.83 | MAPT (0.41) | PPARAKCNJ6KCNJ5KCNJ3SMN1; SMN2 | |
| SCHEMBL29780988 | 0.83 | MAPT (0.41) | PPARAKCNJ6KCNJ5KCNJ3SMN1; SMN2 | |
| SCHEMBL30253451 | 0.79 | GRK2 (0.43) | PPARASMN1; SMN2POLBKMT2AHPGD | |
| SCHEMBL19463254 | 0.79 | MAPT (0.45) | PPARAKCNJ6KCNJ3HPGDKEAP1 | |
| SCHEMBL30672491 | 0.77 | NPC1 (0.51) | KCNJ6KCNJ5KCNJ3SMN1; SMN2CRACR2A | |
| SCHEMBL29052524 | 0.76 | PPARA (0.52) | PPARARPA1SMN1; SMN2NOTUMMEN1 | |
| SCHEMBL19642645 | 0.75 | SMN1; SMN2 (0.58) | PPARARPA1SMN1; SMN2POLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116583287-A | Pyridazinone heterocyclic compound, preparation method and application thereof | 四川科伦博泰生物医药股份有限公司 | 2023-08-11 | — | — | CN | disclosed |
| WO-2022166610-A1 | PYRIDAZINONE HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | 四川科伦博泰生物医药股份有限公司 | 2022-08-11 | — | — | WO | disclosed |