Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 14/20 | 0.56 |
| ▸ | FLT3 | P36888 | 14/20 | 0.56 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.49 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.49 |
| ▸ | KIT | P10721 | 1/20 | 0.49 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.49 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.49 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.49 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.49 |
| ▸ | RPS6KB2 | Q9UBS0 | 1/20 | 0.49 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.49 |
| ▸ | PTK2 | Q05397 | 6/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29052199 | 0.80 | FLT3 (0.49) | CHEK1FLT3AURKARPS6KA5RPS6KA4 | |
| SCHEMBL29051705 | 0.78 | FLT3 (0.58) | CHEK1FLT3AURKARPS6KA5RPS6KA4 | |
| SCHEMBL29051729 | 0.78 | FLT3 (0.48) | CHEK1FLT3 | |
| SCHEMBL29052381 | 0.77 | FLT3 (0.52) | CHEK1FLT3AURKACDK2PTK2 | |
| SCHEMBL18354601 | 0.77 | PTK2 (0.75) | FLT3AURKACDK2PTK2 | |
| SCHEMBL23754838 | 0.75 | FLT3 (0.60) | CHEK1FLT3KITRPS6KB1 | |
| SCHEMBL30086202 | 0.75 | FLT3 (0.60) | CHEK1FLT3KITRPS6KB1 | |
| SCHEMBL29052136 | 0.75 | FLT3 (0.46) | CHEK1FLT3AURKARPS6KA5RPS6KA4 | |
| SCHEMBL17545090 | 0.75 | FLT3 (0.75) | CHEK1FLT3KITRPS6KB1 | |
| SCHEMBL23764827 | 0.75 | CHEK1 (0.75) | CHEK1FLT3KITRPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116332910-A | 2-aminopyrimidine derivatives as kinase inhibitors, preparation and use thereof | 江苏威凯尔医药科技有限公司 | 2023-06-27 | — | — | CN | disclosed |