Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 14/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 12/20 | 0.46 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.43 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 3/20 | 0.41 |
| ▸ | JAK2 | O60674 | 2/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.40 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.40 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.40 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.40 |
| ▸ | RPS6KB2 | Q9UBS0 | 1/20 | 0.40 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.40 |
| ▸ | ULK1 | O75385 | 1/20 | 0.40 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29051857 | 0.90 | PTK2 (0.47) | FLT3CHEK1PTK2PTK2BBTK | |
| SCHEMBL29051729 | 0.90 | FLT3 (0.48) | FLT3CHEK1BTKJAK2 | |
| SCHEMBL29052199 | 0.89 | FLT3 (0.49) | FLT3CHEK1JAK2AURKARPS6KA5 | |
| SCHEMBL29051884 | 0.85 | FLT3 (0.45) | FLT3CHEK1PTK2PTK2BJAK2 | |
| Hydrochloric Acid SCHEMBL29051821 | 0.82 | PTK2 (0.45) | PTK2PTK2BBTK | |
| SCHEMBL29051940 | 0.79 | FLT3 (0.46) | FLT3CHEK1PTK2PTK2BBTK | |
| SCHEMBL29051907 | 0.79 | BTK (0.45) | FLT3CHEK1BTKJAK2 | |
| SCHEMBL29052266 | 0.79 | INSR (0.46) | FLT3CHEK1PTK2PTK2BBTK | |
| SCHEMBL29051865 | 0.79 | FLT3 (0.47) | FLT3CHEK1PTK2PTK2BBTK | |
| SCHEMBL29052409 | 0.78 | FLT3 (0.44) | FLT3CHEK1JAK2KITRPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116332910-A | 2-aminopyrimidine derivatives as kinase inhibitors, preparation and use thereof | 江苏威凯尔医药科技有限公司 | 2023-06-27 | — | — | CN | disclosed |