Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 13/20 | 0.58 |
| ▸ | CHEK1 | O14757 | 12/20 | 0.58 |
| ▸ | PTK2 | Q05397 | 8/20 | 0.54 |
| ▸ | PTK2B | Q14289 | 3/20 | 0.54 |
| ▸ | AURKA | O14965 | 2/20 | 0.54 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.54 |
| ▸ | CDK2 | P24941 | 2/20 | 0.54 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.54 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.54 |
| ▸ | PLK4 | O00444 | 1/20 | 0.54 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.54 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.54 |
| ▸ | JAK2 | O60674 | 1/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.54 |
| ▸ | STK16 | O75716 | 1/20 | 0.54 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.54 |
| ▸ | PAK4 | O96013 | 1/20 | 0.54 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.54 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29051865 | 0.91 | FLT3 (0.47) | FLT3CHEK1PTK2PTK2BAURKA | |
| SCHEMBL29051940 | 0.90 | FLT3 (0.46) | FLT3CHEK1PTK2PTK2BAURKA | |
| SCHEMBL29052266 | 0.89 | INSR (0.46) | FLT3CHEK1PTK2PTK2BNTRK1 | |
| SCHEMBL29051857 | 0.87 | PTK2 (0.47) | FLT3CHEK1PTK2PTK2BAURKA | |
| SCHEMBL29052199 | 0.80 | FLT3 (0.49) | FLT3CHEK1AURKARPS6KB1CDK2 | |
| SCHEMBL29051738 | 0.80 | PTK2 (0.50) | FLT3CHEK1PTK2INSRMET | |
| SCHEMBL29051729 | 0.80 | FLT3 (0.48) | FLT3CHEK1JAK2TYK2JAK3 | |
| SCHEMBL29052169 | 0.78 | CHEK1 (0.56) | FLT3CHEK1PTK2AURKARPS6KB1 | |
| SCHEMBL26098324 | 0.78 | FLT3 (0.63) | FLT3CHEK1RPS6KB1KIT | |
| SCHEMBL29052136 | 0.77 | FLT3 (0.46) | FLT3CHEK1PTK2PTK2BAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116332910-A | 2-aminopyrimidine derivatives as kinase inhibitors, preparation and use thereof | 江苏威凯尔医药科技有限公司 | 2023-06-27 | — | — | CN | disclosed |