Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 2/20 | 0.49 |
| ▸ | CA1 | P00915 | 2/20 | 0.48 |
| ▸ | CA2 | P00918 | 2/20 | 0.48 |
| ▸ | PPARG | P37231 | 6/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | PHGDH | O43175 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL981562 | 0.90 | MCL1 (0.50) | PTGESPPARGHDAC1PHGDHMCL1 | |
| SCHEMBL976632 | 0.83 | PTGES (0.67) | PTGESCA1CA2LMNAHDAC1 | |
| SCHEMBL12949159 | 0.75 | PTGES (0.65) | PTGESCA1CA2LMNAMEN1 | |
| SCHEMBL12949253 | 0.74 | LMNA (0.59) | PTGESCA1CA2LMNAHDAC6 | |
| SCHEMBL13850449 | 0.72 | PTGES (0.61) | PTGESCA1CA2HDAC1HDAC6 | |
| SCHEMBL13075399 | 0.72 | CA1 (0.50) | PTGESCA1CA2LMNAHDAC1 | |
| SCHEMBL12949066 | 0.72 | PTGES (0.61) | PTGESCA1CA2LMNAMCL1 | |
| SCHEMBL12949067 | 0.72 | PTGES (0.61) | PTGESCA1CA2LMNAMEN1 | |
| SCHEMBL13850696 | 0.70 | PTGES (0.65) | PTGESCA1CA2LMNAMEN1 | |
| SCHEMBL979262 | 0.70 | PTGES (0.72) | PTGESCA1CA2LMNAMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2217566-A1 | BIS-(SULFONYLAMINO) DERIVATIVES IN THERAPY 066 | AstraZeneca AB (SE) | 2010-08-18 | — | — | EP | claimed |
| WO-2009064251-A1 | BIS-(SULFONYLAMINO) DERIVATIVES IN THERAPY 066 | ASTRAZENECA AB (SE) | 2009-05-22 | — | — | WO | claimed |