Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Prednisolone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 14/20 | 0.80 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.80 |
| ▸ | PGR | P06401 | 4/20 | 0.80 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.80 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.80 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.80 |
| ▸ | TNF | P01375 | 1/20 | 0.80 |
| ▸ | IL6 | P05231 | 1/20 | 0.80 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.80 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.80 |
| ▸ | AR | P10275 | 1/20 | 0.80 |
| ▸ | GLUL | P15104 | 1/20 | 0.80 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.80 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.80 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.80 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.58 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.58 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Prednisolone SCHEMBL29170842 | 0.93 | NR3C1 (0.79) | NR3C1HIF1APGRHSD17B10CYP3A4 | |
| Prednisolone SCHEMBL5524347 | 0.91 | NR3C1 (0.93) | NR3C1HIF1APGRHSD17B10CYP3A4 | |
| Prednisolone SCHEMBL28451307 | 0.90 | NR3C1 (0.91) | NR3C1HIF1APGRHSD17B10CYP3A4 | |
| Prednisolone SCHEMBL1803463 | 0.90 | NR3C1 (0.91) | NR3C1HIF1APGRHSD17B10CYP3A4 | |
| Prednisolone SCHEMBL28480768 | 0.89 | NR3C1 (0.96) | NR3C1HIF1APGRHSD17B10CYP3A4 | |
| Prednisolone SCHEMBL23863778 | 0.89 | NR3C1 (1.00) | NR3C1HIF1APGRHSD17B10CYP3A4 | |
| Prednisolone SCHEMBL4449434 | 0.89 | NR3C1 (1.00) | NR3C1HIF1APGRHSD17B10CYP3A4 | |
| Prednisolone SCHEMBL11413677 | 0.89 | NR3C1 (1.00) | NR3C1HIF1APGRHSD17B10CYP3A4 | |
| Prednisolone SCHEMBL2597917 | 0.89 | NR3C1 (1.00) | NR3C1HIF1APGRHSD17B10CYP3A4 | |
| Prednisolone SCHEMBL12396679 | 0.89 | NR3C1 (1.00) | NR3C1HIF1APGRHSD17B10CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116615210-A | Novel anuclear cells as a source for the treatment of platelet-rich plasma-dependent disorders | 血小板生源说股份有限公司 | 2023-08-18 | — | — | CN | disclosed |