Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of (R)-Ibuprophen. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 5/20 | 1.00 |
| ▸ | PTGS2 known ✓ | P35354 | 5/20 | 1.00 |
| ▸ | CXCR1 | P25024 | 5/20 | 1.00 |
| ▸ | CXCR2 | P25025 | 5/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 2/20 | 1.00 |
| ▸ | AKR1C3 | P42330 | 2/20 | 1.00 |
| ▸ | ALB | P02768 | 1/20 | 1.00 |
| ▸ | ESR1 | P03372 | 1/20 | 1.00 |
| ▸ | ALOX5 | P09917 | 1/20 | 1.00 |
| ▸ | RARB | P10826 | 1/20 | 1.00 |
| ▸ | ADRB3 | P13945 | 1/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 1/20 | 1.00 |
| ▸ | HTR2A | P28223 | 1/20 | 1.00 |
| ▸ | NR1I3 | Q14994 | 1/20 | 1.00 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 1.00 |
| ▸ | CXCL8 | P10145 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | AKR1C2 | P52895 | 1/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ibuprofen SCHEMBL1651685 | 1.00 | PTGS1 (1.00) | PTGS1PTGS2CXCR1CXCR2LMNA | |
| Ibuprofen SCHEMBL19439559 | 1.00 | PTGS1 (1.00) | PTGS1PTGS2CXCR1CXCR2LMNA | |
| Ibuprofen SCHEMBL7037276 | 1.00 | PTGS1 (1.00) | PTGS1PTGS2CXCR1CXCR2LMNA | |
| Dexibuprofen SCHEMBL30091137 | 1.00 | PTGS1 (1.00) | PTGS1PTGS2CXCR1CXCR2LMNA | |
| Ibuprofen SCHEMBL3001 | 1.00 | PTGS1 (1.00) | PTGS1PTGS2CXCR1CXCR2LMNA | |
| Ibuprofen SCHEMBL239446 | 1.00 | PTGS1 (1.00) | PTGS1PTGS2CXCR1CXCR2LMNA | |
| Dexibuprofen SCHEMBL43531 | 1.00 | PTGS1 (1.00) | PTGS1PTGS2CXCR1CXCR2LMNA | |
| Ibuprofen SCHEMBL19439560 | 1.00 | PTGS1 (1.00) | PTGS1PTGS2CXCR1CXCR2LMNA | |
| Ibuprofen SCHEMBL8754799 | 1.00 | PTGS1 (1.00) | PTGS1PTGS2CXCR1CXCR2LMNA | |
| Ibuprofen SCHEMBL5971382 | 0.98 | PTGS1 (0.96) | PTGS1PTGS2CXCR1CXCR2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 19262 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3874789-B1 | TERRESTRIAL OR NON-TERRESTRIAL WIRELESS COMMUNICATION SYSTEMS | FRAUNHOFER GES FORSCHUNG (DE) | 2026-05-20 | — | — | EP | claimed |
| CN-122029177-A | Oligonucleotides containing multiple ligands and/or lipids | 阿达尔克斯制药有限公司 | 2026-05-12 | — | — | CN | claimed |
| CN-122029176-A | Containing a plurality of oligonucleotides modified oligonucleotides | 阿达尔克斯制药有限公司 | 2026-05-12 | — | — | CN | claimed |
| CN-122028913-A | Oligonucleotides containing ligands in nucleobases, 2 'or 3' positions | 阿达尔克斯制药有限公司 | 2026-05-12 | — | — | CN | claimed |
| EP-3705439-B1 | BUILDING INTERIOR HUMAN FLOW PREDICTION SYSTEM AND PREDICTION METHOD | HITACHI LTD (JP) | 2026-04-29 | — | — | EP | claimed |
| EP-2512967-B1 | ELEVATOR SECURITY SYSTEM | OTIS ELEVATOR CO (US) | 2026-04-01 | — | — | EP | claimed |
| EP-4269172-B1 | AIRCRAFT PASSENGER CABIN LIGHT, AIRCRAFT PASSENGER CABIN LIGHTING SYSTEM, AND METHOD OF INSTALLING AN AIRCRAFT PASSENGER CABIN LIGHTING SYSTEM | GOODRICH LIGHTING SYSTEMS GMBH & CO KG (DE) | 2026-03-25 | — | — | EP | claimed |
| EP-4387292-B1 | COMMUNICATION METHOD, COMMUNICATION SYSTEM, AND ELECTRONIC DEVICE | HONOR DEVICE CO LTD (CN) | 2026-03-18 | — | — | EP | claimed |
| EP-4550858-B1 | SOFTWARE DESIGN METHOD FOR INTELLIGENT VEHICLE-MOUNTED TERMINAL BASED ON MICROSERVICE ARCHITECTURE | XIAMEN KING LONG UNITED AUTOMOTIVE IND CO LTD (CN) | 2026-02-11 | — | — | EP | claimed |
| US-12545750-B2 | Method for the diimide hydrogenation of emulsified unsaturated polymers | PARKER DANE K (US) | 2026-02-10 | — | — | US | claimed |
| EP-0025254-B1 | A TELEPHONE SET | Chiou, Suchi (TW) | 1984-09-26 | — | — | EP | claimed |
| WO-1984002697-A1 | CONTROL SYSTEM FOR ELEVATOR DEVICES | MASCHF AUGSBURG NUERNBERG AG (DE) | 1984-07-19 | — | — | WO | claimed |
| EP-0057852-B1 | AUTOMATIC TELEPHONE ANSWERING MACHINE FOR PRIVATE AUTOMATIC BRANCH EXCHANGES | Neumann Elektronik GmbH (DE) | 1984-06-13 | — | — | EP | claimed |
| EP-0036979-B1 | SIGNALLING PROCESS FOR TELECOMMUNICATION EXCHANGES, ESPECIALLY TELEPHONE EXCHANGES | SIEMENS-ALBIS AKTIENGESELLSCHAFT (CH) | 1984-03-14 | — | — | EP | claimed |
| EP-0018617-B1 | SYSTEM FOR EXCHANGING CODED MESSAGES BETWEEN STATIONS | COMPAGNIE INDUSTRIELLE DES TELECOMMUNICATIONS CIT-ALCATEL S.A. dite: (FR) | 1983-12-28 | — | — | EP | claimed |
| EP-0016155-B1 | REMOTE SUPERVISORY SYSTEM | BARTELINK, Everhard H.B. (US) | 1983-07-06 | — | — | EP | claimed |
| EP-0079463-A1 | Method and circuit for registering the loop current criteria in a telecommunication exchange | Felten & Guilleaume Fernmeldeanlagen GmbH (DE) | 1983-05-25 | — | — | EP | claimed |
| EP-0062844-A1 | Substituted benzo(de)isoquinolines, processes for their preparation, and their application as pharmaceutical preparations | Beiersdorf Aktiengesellschaft (DE) | 1982-10-20 | — | — | EP | claimed |
| EP-0057852-A2 | Automatic telephone answering machine for private automatic branch exchanges | Neumann Elektronik GmbH (DE) | 1982-08-18 | — | — | EP | claimed |
| EP-0036979-A1 | Signalling process for telecommunication exchanges, especially telephone exchanges | SIEMENS-ALBIS AKTIENGESELLSCHAFT (CH) | 1981-10-07 | — | — | EP | claimed |