Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dexibuprofen. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 5/20 | 1.00 |
| ▸ | PTGS2 known ✓ | P35354 | 5/20 | 1.00 |
| ▸ | CXCR1 | P25024 | 5/20 | 1.00 |
| ▸ | CXCR2 | P25025 | 5/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 2/20 | 1.00 |
| ▸ | AKR1C3 | P42330 | 2/20 | 1.00 |
| ▸ | ALB | P02768 | 1/20 | 1.00 |
| ▸ | ESR1 | P03372 | 1/20 | 1.00 |
| ▸ | ALOX5 | P09917 | 1/20 | 1.00 |
| ▸ | RARB | P10826 | 1/20 | 1.00 |
| ▸ | ADRB3 | P13945 | 1/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 1/20 | 1.00 |
| ▸ | HTR2A | P28223 | 1/20 | 1.00 |
| ▸ | NR1I3 | Q14994 | 1/20 | 1.00 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 1.00 |
| ▸ | CXCL8 | P10145 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | AKR1C2 | P52895 | 1/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ibuprofen SCHEMBL1651685 | 1.00 | PTGS1 (1.00) | PTGS1PTGS2CXCR1CXCR2LMNA | |
| Ibuprofen SCHEMBL19439559 | 1.00 | PTGS1 (1.00) | PTGS1PTGS2CXCR1CXCR2LMNA | |
| Ibuprofen SCHEMBL7037276 | 1.00 | PTGS1 (1.00) | PTGS1PTGS2CXCR1CXCR2LMNA | |
| Dexibuprofen SCHEMBL30091137 | 1.00 | PTGS1 (1.00) | PTGS1PTGS2CXCR1CXCR2LMNA | |
| Ibuprofen SCHEMBL3001 | 1.00 | PTGS1 (1.00) | PTGS1PTGS2CXCR1CXCR2LMNA | |
| Ibuprofen SCHEMBL239446 | 1.00 | PTGS1 (1.00) | PTGS1PTGS2CXCR1CXCR2LMNA | |
| (R)-Ibuprophen SCHEMBL29057 | 1.00 | PTGS1 (1.00) | PTGS1PTGS2CXCR1CXCR2LMNA | |
| Ibuprofen SCHEMBL19439560 | 1.00 | PTGS1 (1.00) | PTGS1PTGS2CXCR1CXCR2LMNA | |
| Ibuprofen SCHEMBL8754799 | 1.00 | PTGS1 (1.00) | PTGS1PTGS2CXCR1CXCR2LMNA | |
| Ibuprofen SCHEMBL5971382 | 0.98 | PTGS1 (0.96) | PTGS1PTGS2CXCR1CXCR2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 13209 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3841097-B1 | 2,6-BIS(((1H-BENZO[D]IMIDAZOL-2-YL)THIO)METHYL)PYRIDINE AND N2,N6-DIBENZYLPYRIDINE-2,6-DICARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS PHOSPHOINOSITIDE 3-KINASE (PI3K) INHIBITORS FOR TREATING CANCER | BIOMEDICAL RES FOUNDATION OF THE ACADEMY OF ATHENS BRFAA (GR) | 2026-05-20 | — | — | EP | claimed |
| EP-4255391-B1 | LUMINOL FOR USE IN THE TREATMENT OF SEQUELAE OF A SARS-COV-2 INFECTION | METRIOPHARM AG (CH) | 2026-05-06 | — | — | EP | claimed |
| US-12605432-B2 | Combinations for antigen based therapy | DIAMYD MEDICAL AB (SE) | 2026-04-21 | — | — | US | claimed |
| US-12600696-B2 | Aromatic compounds | Xeniopro GmbH (DE) | 2026-04-14 | — | — | US | claimed |
| US-20260097023-A1 | UNIT ORAL DOSE COMPOSITIONS COMPOSED OF IBUPROFEN OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AND FAMOTIDINE OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF FOR THE TREATMENT OF ACUTE PAIN AND THE REDUCTION OF THE SEVERITY AND/OR RISK OF HEARTBURN AND/OR UPSET STOMACH | SCHABAR RES ASSOCIATES LLC (US) | 2026-04-09 | — | — | US | claimed |
| US-20260069532-A1 | METHOD FOR MORSELIZING AND/OR TARGETING PHARMACEUTICALLY ACTIVE PRINCIPLES TO SYNOVIAL TISSUE | MEDINCELL S.A. (FR) | 2026-03-12 | — | — | US | claimed |
| US-12569451-B2 | Bio-inspired tissue-adhesive hydrogel patch and uses thereof | Cellartgen Inc. (KR) | 2026-03-10 | — | — | US | claimed |
| US-12558309-B2 | Method for morselizing and/or targeting pharmaceutically active principles to synovial tissue | MEDINCELL S.A. (FR) | 2026-02-24 | — | — | US | claimed |
| US-20260041660-A1 | Compositions And Methods for Treating Acute Respiratory Distress Syndrome (ARDS) And Inflammatory Disorders Caused by Corona Viruses and Other Respiratory Pathogens or Agents That Mediate Pulmonary Injury, Inflammation or Acute Respiratory Distress, And Related Compositions and Methods for Treating and Preventing Human SARS Coronavirus Infection, COVID-19 Disease and Related Symptoms | CHANG RICHARD L (US) | 2026-02-12 | — | — | US | claimed |
| US-12514846-B2 | Unit oral dose compositions composed of ibuprofen or a pharmaceutically acceptable salt thereof and famotidine or a pharmaceutically acceptable salt thereof for the treatment of acute pain and the reduction of the severity and/or risk of heartburn and/or upset stomach | SCHABAR RESEARCH ASSOCIATES LLC (US) | 2026-01-06 | — | — | US | claimed |
| EP-0459695-B1 | Taste masking and sustained release coatings for pharmaceuticals | MCNEIL PPC INC (US) | 1995-03-15 | — | — | EP | claimed |
| EP-0602112-A1 | HIGH CONTENT IBUPROFEN AGGLOMERATES AND PROCESS TO PREPARE THEM | The Boots Company PLC (GB) | 1994-06-22 | — | — | EP | claimed |
| US-5240712-A | Solid sustained release unit dosage forms of 2-(4-isobutylphenyl)propionic acid | THE BOOTS COMPANY PLC (GB) | 1993-08-31 | — | — | US | claimed |
| WO-1993004676-A1 | HIGH CONTENT IBUPROFEN AGGLOMERATES AND PROCESS TO PREPARE THEM | THE BOOTS COMPANY PLC (GB) | 1993-03-18 | — | — | WO | claimed |
| US-4701470-A | Treatment of Type II Herpes virus with ibuprofen | THE UPJOHN COMPANY (US) | 1987-10-20 | — | — | US | claimed |
| US-4447451-A | ADMINISTERING IBUPROFEN | THE UPJOHN MANUFACTURING COMPANY M (US) | 1984-05-08 | — | — | US | claimed |
| US-4439450-A | Treatment of the blood-brain barrier with ibuprofen | THE UPJOHN MANUFACTURING COMPANY M (US) | 1984-03-27 | — | — | US | claimed |
| EP-0070714-A1 | Use of ibuprofen or flurbiprofen for the manufacture of a medicament for treating respiratory disorders | THE UPJOHN COMPANY (US) | 1983-01-26 | — | — | EP | claimed |
| US-4346108-A | Method for preventing adhesion formation | THE UPJOHN MANUFACTURING COMPANY M (US) | 1982-08-24 | — | — | US | claimed |
| US-4154962-A | Synthesis of hydratropic acid and some of its alkyl derivatives | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) | 1979-05-15 | — | — | US | claimed |