Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 14/20 | 0.39 |
| ▸ | PDE4A | P27815 | 13/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 12/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30350700 | 0.80 | FFAR4 (0.40) | PDE4DPDE4APDE4BPDE4CLRRK2 | |
| SCHEMBL2910247 | 0.80 | FFAR4 (0.40) | PDE4DPDE4APDE4BPDE4CLRRK2 | |
| SCHEMBL2905574 | 0.77 | PDE4A (0.42) | PDE4DPDE4APDE4BPDE4CLRRK2 | |
| SCHEMBL2906852 | 0.75 | PDE4B (0.43) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL2908835 | 0.74 | PDE4B (0.35) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL2414839 | 0.74 | PDE4A (0.42) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL2907660 | 0.73 | TRPM8 (0.33) | — | |
| SCHEMBL4148746 | 0.71 | MEN1 (0.36) | PDE4DPDE4APDE4BPDE4CLRRK2 | |
| SCHEMBL20064142 | 0.71 | PDE4B (0.47) | PDE4DPDE4APDE4BPDE4CKCNH2 | |
| SCHEMBL20063995 | 0.69 | PDE4D (0.51) | PDE4DPDE4APDE4BPDE4CKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1692109-B1 | PHOSPHODIESTERASE 4 INHIBITORS, INCLUDING N-SUBSTITUTED DIARYLAMINE ANALOGS | MEMORY PHARM CORP (US) | 2010-08-18 | — | — | EP | disclosed |
| US-20090118270-A1 | PHOSPHODIESTERASE 4 INHIBITORS | TALAMAS FRANCISCO XAVIER | 2009-05-07 | — | — | US | disclosed |
| US-20070049611-A1 | Phosphodiesterase 4 inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 2007-03-01 | — | — | US | disclosed |
| US-20050222207-A1 | Phosphodiesterase 4 inhibitors, including N-substituted diarylamine analogs | MEMORY PHARMACEUTICAL CORPORATION | 2005-10-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070049611-A1 | Phosphodiesterase 4 inhibitors | PDE4A, PDE3B, PDE4B | PDE4D 6/4885PDE4A 1/4885PDE4B 3/4885 |
| US-20050222207-A1 | Phosphodiesterase 4 inhibitors, including N-substituted diarylamine analogs | PDE4A, PDE4B, PDE3B | PDE4D 6/4885PDE4A 1/4885PDE4B 2/4885 |
| US-20090118270-A1 | PHOSPHODIESTERASE 4 INHIBITORS | PDE4A, PDE3B, PDE4B | PDE4D 6/4885PDE4A 1/4885PDE4B 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.