Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT2B | Q92831 | 8/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17559093 | 0.80 | KAT2B (0.47) | KAT2BHPGDSMN1; SMN2LMNA | |
| SCHEMBL8535608 | 0.77 | HPGD (0.47) | KAT2BHPGDSMN1; SMN2CDK8ACVR1 | |
| SCHEMBL590272 | 0.75 | KDR (0.43) | LMNA | |
| SCHEMBL19377004 | 0.73 | KAT2B (0.47) | KAT2BHPGDSMN1; SMN2GAA | |
| SCHEMBL16006573 | 0.72 | ALKBH5 (0.43) | HPGDLMNA | |
| SCHEMBL17571754 | 0.70 | KAT2B (0.44) | KAT2BHPGDLMNA | |
| SCHEMBL18436503 | 0.68 | BRD4 (0.61) | — | |
| SCHEMBL19533290 | 0.68 | CDK8 (0.34) | HPGDCDK8ACVR1 | |
| SCHEMBL16158053 | 0.67 | MAPT (0.36) | LMNAGAA | |
| SCHEMBL434996 | 0.67 | NPSR1 (0.58) | HPGDSMN1; SMN2LMNACDK8ACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116635371-A | Polycyclic pyridazinone derivative serving as SOS1 inhibitor, and preparation method and application thereof | 苏州阿尔脉生物科技有限公司 | 2023-08-22 | — | — | CN | disclosed |