Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Biphenyl. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | CES2 | O00748 | 1/20 | 0.48 |
| ▸ | CES1 | P23141 | 1/20 | 0.48 |
| ▸ | MMP3 | P08254 | 1/20 | 0.48 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | KMO | O15229 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Biphenyl SCHEMBL15332958 | 0.97 | SMN1; SMN2 (0.67) | SMN1; SMN2MAPTALDH1A1L3MBTL1PTGS2 | |
| Biphenyl SCHEMBL538359 | 0.97 | SMN1; SMN2 (0.67) | SMN1; SMN2MAPTALDH1A1L3MBTL1PTGS2 | |
| Biphenyl SCHEMBL29059196 | 0.97 | SMN1; SMN2 (0.67) | SMN1; SMN2MAPTALDH1A1L3MBTL1PTGS2 | |
| Biphenyl SCHEMBL31099242 | 0.94 | SMN1; SMN2 (0.64) | SMN1; SMN2MAPTALDH1A1L3MBTL1PTGS2 | |
| Acetic Acid SCHEMBL27559163 | 0.94 | SMN1; SMN2 (0.64) | SMN1; SMN2MAPTALDH1A1L3MBTL1PTGS2 | |
| Biphenyl SCHEMBL1157851 | 0.94 | SMN1; SMN2 (0.64) | SMN1; SMN2MAPTALDH1A1L3MBTL1PTGS2 | |
| Biphenyl SCHEMBL11759013 | 0.94 | SMN1; SMN2 (0.64) | SMN1; SMN2MAPTALDH1A1L3MBTL1PTGS2 | |
| Biphenyl SCHEMBL8025407 | 0.94 | SMN1; SMN2 (0.64) | SMN1; SMN2MAPTALDH1A1L3MBTL1PTGS2 | |
| Biphenyl SCHEMBL4205333 | 0.94 | SMN1; SMN2 (0.64) | SMN1; SMN2MAPTALDH1A1L3MBTL1PTGS2 | |
| Biphenyl SCHEMBL11131611 | 0.94 | SMN1; SMN2 (0.64) | SMN1; SMN2MAPTALDH1A1L3MBTL1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8975437-B2 | Process for the continuous transvinylation of carboxylic acids with vinyl acetate | CELANESE INTERNATIONAL CORPORATION (US) | 2015-03-10 | — | — | US | disclosed |
| US-8921593-B2 | Process for the semi-continuous transvinylation of carboxylic acids with vinyl acetate | CELANESE INTERNATIONAL CORPORATION (US) | 2014-12-30 | — | — | US | disclosed |
| EP-2566840-A1 | PROCESS FOR THE CONTINUOUS TRANSVINYLATION OF CARBOXYLIC ACIDS WITH VINYL ACETATE | Celanese International Corporation (US) | 2013-03-13 | — | — | EP | disclosed |
| EP-2566841-A1 | PROCESS FOR THE SEMI-CONTINUOUS TRANSVINYLATION OF CARBOXYLIC ACIDS WITH VINYL ACETATE | Celanese International Corporation (US) | 2013-03-13 | — | — | EP | disclosed |
| WO-2011139361-A1 | PROCESS FOR THE SEMI-CONTINUOUS TRANSVINYLATION OF CARBOXYLIC ACIDS WITH VINYL ACETATE | CELANESE INTERNATIONAL CORPORATION (US) | 2011-11-10 | — | — | WO | disclosed |
| WO-2011139360-A1 | PROCESS FOR THE CONTINUOUS TRANSVINYLATION OF CARBOXYLIC ACIDS WITH VINYL ACETATE | CELANESE INTERNATIONAL CORPORATION (US) | 2011-11-10 | — | — | WO | disclosed |
| US-20110275852-A1 | Process for the semi-continuous transvinylation of carboxylic acids with vinyl acetate | CELANESE INTERNATIONAL CORPORATION | 2011-11-10 | — | — | US | disclosed |
| US-20110275853-A1 | Process for the continuous transvinylation of carboxylic acids with vinyl acetate | CELANESE INTERNATIONAL CORPORATION | 2011-11-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110275853-A1 | Process for the continuous transvinylation of carboxylic acids with vinyl acetate | TECR, ALAD, DDC | SMN1; SMN2 3575/4885MAPT 4054/4885ALDH1A1 121/4885 |
| US-20110275852-A1 | Process for the semi-continuous transvinylation of carboxylic acids with vinyl acetate | TECR, ALAD, DECR1 | SMN1; SMN2 3746/4885MAPT 3989/4885ALDH1A1 118/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.