Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Biphenyl. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.67 |
| ▸ | MAPT | P10636 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.52 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | CES2 | O00748 | 1/20 | 0.50 |
| ▸ | CES1 | P23141 | 1/20 | 0.50 |
| ▸ | MMP3 | P08254 | 1/20 | 0.50 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | KMO | O15229 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Biphenyl SCHEMBL29059196 | 1.00 | SMN1; SMN2 (0.67) | SMN1; SMN2MAPTALDH1A1L3MBTL1PTGS2 | |
| Biphenyl SCHEMBL15332958 | 1.00 | SMN1; SMN2 (0.67) | SMN1; SMN2MAPTALDH1A1L3MBTL1PTGS2 | |
| Biphenyl SCHEMBL11759013 | 0.97 | SMN1; SMN2 (0.64) | SMN1; SMN2MAPTALDH1A1L3MBTL1PTGS2 | |
| Biphenyl SCHEMBL1308540 | 0.97 | SMN1; SMN2 (0.64) | SMN1; SMN2MAPTALDH1A1L3MBTL1PTGS2 | |
| Acetic Acid SCHEMBL27559163 | 0.97 | SMN1; SMN2 (0.64) | SMN1; SMN2MAPTALDH1A1L3MBTL1PTGS2 | |
| Biphenyl SCHEMBL1157851 | 0.97 | SMN1; SMN2 (0.64) | SMN1; SMN2MAPTALDH1A1L3MBTL1PTGS2 | |
| Biphenyl SCHEMBL31099242 | 0.97 | SMN1; SMN2 (0.64) | SMN1; SMN2MAPTALDH1A1L3MBTL1PTGS2 | |
| Biphenyl SCHEMBL4205333 | 0.97 | SMN1; SMN2 (0.64) | SMN1; SMN2MAPTALDH1A1L3MBTL1PTGS2 | |
| Biphenyl SCHEMBL8025407 | 0.97 | SMN1; SMN2 (0.64) | SMN1; SMN2MAPTALDH1A1L3MBTL1PTGS2 | |
| Biphenyl SCHEMBL11131611 | 0.97 | SMN1; SMN2 (0.64) | SMN1; SMN2MAPTALDH1A1L3MBTL1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2231 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025243208-A2 | PROCESS FOR THE PREPARATION AND/OR PURIFICATION OF POLYETHYLENE GLYCOL AND ITS DERIVATIVES, OBTAINED PRODUCT AND USES THEREOF | HOVIONE - FARMACIÊNCIA, SA (PT) | 2025-11-27 | — | — | WO | claimed |
| CN-116354838-B | Method for recycling p-hydroxyphenylglycine and o-hydroxyphenylglycine | 安徽普洛生物科技有限公司 | 2024-12-13 | — | — | CN | claimed |
| CN-118496265-A | Production process of high-purity glyphosate | 福华通达化学股份公司 | 2024-08-16 | — | — | CN | claimed |
| WO-2023221852-A1 | COMPOUND PHARMACEUTICAL COMPOSITION FOR TREATING GLAUCOMA AND USE THEREOF | 沈阳药科大学 | 2023-11-23 | — | — | WO | claimed |
| CN-116621689-A | L-lysine-biphenyl acetate, and preparation method and application thereof | 山东省药学科学院 | 2023-08-22 | — | — | CN | claimed |
| CN-115651266-B | Heterogeneous polymethacrylimide wave-absorbing foam and preparation method thereof | 航天特种材料及工艺技术研究所 | 2023-07-18 | — | — | CN | claimed |
| CN-116354838-A | Method for recycling p-hydroxyphenylglycine and o-hydroxyphenylglycine | 安徽普洛生物科技有限公司 | 2023-06-30 | — | — | CN | claimed |
| CN-217119404-U | Biphenylacetic acid purification device | 河南羚锐生物药业有限公司 | 2022-08-05 | — | — | CN | claimed |
| CN-108586178-B | Process for the manufacture of nitriles and their corresponding amines | 中国石油化工股份有限公司 | 2022-02-11 | — | — | CN | claimed |
| CN-113121492-A | Vilandiolo intermediate, preparation method and application thereof | 天津药业研究院股份有限公司 | 2021-07-16 | — | — | CN | claimed |
| WO-1997010227-A1 | BENZOTHIAZOLONE DERIVATIVES | ASTRA PHARMACEUTICALS LIMITED (GB) | 1997-03-20 | — | — | WO | claimed |
| US-5034441-A | Molding material containing an organo phosphate and a polyoxyalkylene compound with a styrene resin | IDEMITSU KOSAN CO., LTD. (JP) | 1991-07-23 | — | — | US | claimed |
| EP-0229947-B1 | NOVEL CRYSTALLINE SALTS OF ARYLOXY-PROPANOLAMINES, THEIR PREPARATION AND THEIR USE | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1991-03-13 | — | — | EP | claimed |
| EP-0396564-A1 | PROCESS FOR THE PREPARATION OF STILBENEDICARBOXYLATE DERIVATIVES | EASTMAN KODAK COMPANY (US) | 1990-11-14 | — | — | EP | claimed |
| EP-0382064-A1 | Styrene-based resin composition and process for producing molding products thereof | IDEMITSU KOSAN COMPANY LIMITED (JP) | 1990-08-16 | — | — | EP | claimed |
| CN-1040987-A | Be used for drug release and chromatographic composition and method thereof | AUSTRALIAN COMMERCIAL RESEARCH (AU) | 1990-04-04 | — | — | CN | claimed |
| CN-1039455-A | Bondedfibre fabric | IDEMITSU KOSAN CO (JP) | 1990-02-07 | — | — | CN | claimed |
| WO-1989003380-A1 | PROCESS FOR THE PREPARATION OF STILBENEDICARBOXYLATE DERIVATIVES | EASTMAN KODAK COMPANY (US) | 1989-04-20 | — | — | WO | claimed |
| US-4789755-A | DEHYDRODIMERIZATION OF METHYL OR PHENYL TOLUATES | EASTMAN KODAK COMPANY (US) | 1988-12-06 | — | — | US | claimed |
| EP-0239354-A2 | 2,2-Dinitrophenylethane derivatives and their application as protecting compounds | Wendstone Chemicals P.L.C. (GB) | 1987-09-30 | — | — | EP | claimed |