Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLP1R | P43220 | 1/20 | 0.42 |
| ▸ | PFKFB3 | Q16875 | 2/20 | 0.39 |
| ▸ | GBA1 | P04062 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | FADS1 | O60427 | 1/20 | 0.36 |
| ▸ | SCN1A | P35498 | 2/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1616447 | 0.81 | KDM4E (0.43) | GLP1RPFKFB3GBA1ALDH1A1KDM4E | |
| SCHEMBL2905970 | 0.74 | GBA1 (0.44) | GLP1RPFKFB3GBA1EGFRMAPK14 | |
| SCHEMBL2904940 | 0.71 | GBA1 (0.47) | GLP1RPFKFB3GBA1EGFRLMNA | |
| SCHEMBL2906202 | 0.71 | GBA1 (0.47) | GLP1RPFKFB3GBA1EGFRLMNA | |
| SCHEMBL2905882 | 0.71 | PRKCQ (0.48) | GLP1RPFKFB3GBA1EGFRALDH1A1 | |
| SCHEMBL2905886 | 0.71 | PRKCQ (0.48) | GLP1RPFKFB3GBA1EGFRALDH1A1 | |
| SCHEMBL3401353 | 0.70 | PFKFB3 (0.41) | GLP1RPFKFB3KDM4ELMNAALOX15 | |
| SCHEMBL2897916 | 0.69 | GLP1R (0.49) | GLP1RPFKFB3GBA1ALDH1A1KDM4E | |
| SCHEMBL4100050 | 0.69 | MAPT (0.43) | PFKFB3ALDH1A1KDM4ELMNATSHR | |
| SCHEMBL2904936 | 0.69 | AURKA (0.56) | GLP1RGBA1EGFRPDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2099763-B1 | 2-AMINOQUINOLINES AS 5-HT(5A) RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-08-11 | — | — | EP | disclosed |