Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 3/20 | 0.56 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.49 |
| ▸ | CD38 | P28907 | 2/20 | 0.47 |
| ▸ | IKBKB | O14920 | 1/20 | 0.46 |
| ▸ | GBA1 | P04062 | 1/20 | 0.43 |
| ▸ | GLP1R | P43220 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | FADS1 | O60427 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3429529 | 0.87 | AURKA (0.51) | AURKARPS6KB1AURKBCD38GBA1 | |
| SCHEMBL2905910 | 0.85 | AURKA (0.53) | AURKARPS6KB1AURKBCD38GBA1 | |
| SCHEMBL4098815 | 0.82 | AURKA (0.46) | AURKARPS6KB1AURKBCD38GBA1 | |
| SCHEMBL2906297 | 0.82 | AURKA (0.41) | AURKARPS6KB1AURKBGBA1GLP1R | |
| SCHEMBL2906202 | 0.82 | GBA1 (0.47) | AURKARPS6KB1GBA1GLP1REGFR | |
| SCHEMBL2904940 | 0.82 | GBA1 (0.47) | AURKARPS6KB1GBA1GLP1REGFR | |
| SCHEMBL2906027 | 0.79 | GBA1 (0.45) | AURKARPS6KB1GBA1GLP1REGFR | |
| SCHEMBL2905882 | 0.77 | PRKCQ (0.48) | AURKARPS6KB1GBA1GLP1REGFR | |
| SCHEMBL2905886 | 0.77 | PRKCQ (0.48) | AURKARPS6KB1GBA1GLP1REGFR | |
| SCHEMBL2905955 | 0.76 | GBA1 (0.45) | AURKARPS6KB1GBA1GLP1REGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8183380-B2 | 2-aminoquinolines | HOFFMANN-LA ROCHE INC. (US) | 2012-05-22 | — | — | US | claimed |
| US-20090227570-A1 | 2-AMINOQUINOLINES | HOFFMANN-LA ROCHE, INC. | 2009-09-10 | — | — | US | claimed |
| EP-2099763-B1 | 2-AMINOQUINOLINES AS 5-HT(5A) RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-08-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090227570-A1 | 2-AMINOQUINOLINES | HTR5A, HTR2C, HTR2A | AURKA 1160/4885RPS6KB1 1064/4885AURKB 1344/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.