Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF4E | P06730 | 2/20 | 0.37 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 4/20 | 0.34 |
| ▸ | GSK3A | P49840 | 3/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 2/20 | 0.33 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.32 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.32 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.32 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.32 |
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | DHFR | P00374 | 1/20 | 0.30 |
| ▸ | IKBKB | O14920 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2912022 | 0.89 | GSK3B (0.34) | EIF4EKAT2BGSK3BGSK3ACDK1 | |
| SCHEMBL2909714 | 0.89 | GSK3B (0.36) | EIF4EGSK3BGSK3AMAP4K4CDK1 | |
| SCHEMBL2907084 | 0.89 | GSK3B (0.37) | EIF4EKAT2BGSK3BGSK3ACDK1 | |
| SCHEMBL2904891 | 0.89 | GSK3B (0.42) | EIF4EGSK3BGSK3AMAP4K4CDK1 | |
| SCHEMBL2911792 | 0.89 | GSK3B (0.36) | EIF4EGSK3BGSK3ACDK1FOLH1 | |
| SCHEMBL2907085 | 0.88 | SCN9A (0.34) | KAT2BGSK3BGSK3AMAP4K4FOLH1 | |
| SCHEMBL2909954 | 0.88 | SCN9A (0.34) | KAT2BGSK3BGSK3AMAP4K4FOLH1 | |
| SCHEMBL2904612 | 0.87 | GSK3B (0.36) | KAT2BGSK3BGSK3ACDK1FOLH1 | |
| SCHEMBL2907197 | 0.87 | SCN9A (0.33) | KAT2BGSK3BGSK3AMAP4K4KDM1A | |
| SCHEMBL2910322 | 0.87 | SCN9A (0.33) | KAT2BGSK3BGSK3AMAP4K4KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537099-B1 | PYRROLE BASED INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | NOVARTIS VACCINES & DIAGNOSTIC (US) | 2010-08-11 | — | — | EP | disclosed |