Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | PRF1 | P14222 | 1/20 | 0.33 |
| ▸ | EP300 | Q09472 | 5/20 | 0.33 |
| ▸ | HAT1 | O14929 | 3/20 | 0.33 |
| ▸ | GSK3B | P49841 | 2/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.31 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.31 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.31 |
| ▸ | NAMPT | P43490 | 2/20 | 0.31 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.31 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.30 |
| ▸ | IKBKB | O14920 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2907197 | 1.00 | SCN9A (0.33) | SCN9APRF1EP300HAT1GSK3B | |
| SCHEMBL2911588 | 0.91 | ALDH1A1 (0.34) | GSK3BGSK3AALDH1A1SMN1; SMN2 | |
| SCHEMBL2911036 | 0.91 | ALDH1A1 (0.34) | GSK3BGSK3AALDH1A1SMN1; SMN2 | |
| SCHEMBL2908179 | 0.90 | MET (0.34) | GSK3BGSK3AALDH1A1SMN1; SMN2 | |
| SCHEMBL2938731 | 0.90 | MET (0.34) | GSK3BGSK3AALDH1A1SMN1; SMN2 | |
| SCHEMBL2907242 | 0.90 | LMNA (0.34) | GSK3BGSK3AALDH1A1SMN1; SMN2 | |
| SCHEMBL2912251 | 0.90 | SMN1; SMN2 (0.40) | GSK3BGSK3AALDH1A1SMN1; SMN2 | |
| SCHEMBL2904193 | 0.90 | SMN1; SMN2 (0.40) | GSK3BGSK3AALDH1A1SMN1; SMN2 | |
| SCHEMBL2904632 | 0.90 | LMNA (0.34) | GSK3BGSK3AALDH1A1SMN1; SMN2 | |
| SCHEMBL2911391 | 0.90 | GSK3B (0.33) | GSK3BGSK3AALDH1A1SMN1; SMN2KAT2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537099-B1 | PYRROLE BASED INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | NOVARTIS VACCINES & DIAGNOSTIC (US) | 2010-08-11 | — | — | EP | disclosed |