Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | LTA4H | P09960 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.45 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.45 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.45 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.45 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.45 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.45 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.44 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2909201 | 0.88 | P2RY12 (0.49) | ALDH1A1KDM4EP2RY12 | |
| SCHEMBL15763878 | 0.87 | KDM4E (0.55) | ALDH1A1KDM4ELTA4HTDP1MAPT | |
| SCHEMBL985553 | 0.87 | NPC1 (0.56) | ALDH1A1KDM4ELTA4H | |
| SCHEMBL984214 | 0.81 | ACKR3 (0.49) | P2RY12 | |
| SCHEMBL2929681 | 0.80 | KDM4E (0.56) | ALDH1A1KDM4ETDP1MEN1KMT2A | |
| SCHEMBL2929687 | 0.80 | KDM4E (0.56) | ALDH1A1KDM4ETDP1MEN1KMT2A | |
| SCHEMBL5670325 | 0.78 | ROCK1 (0.53) | ALDH1A1KDM4EROCK1PRKAB2PRKAG1 | |
| SCHEMBL2899930 | 0.77 | MCL1 (0.52) | ALDH1A1KDM4EMCL1 | |
| SCHEMBL1111239 | 0.76 | P2RY12 (0.52) | MCL1P2RY12 | |
| SCHEMBL12923461 | 0.76 | MAPT (0.41) | ALDH1A1KDM4EMAPTROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2217606-A1 | SOLUBILIZED THIAZOLOPYRIDINES | Sirtris Pharmaceuticals, Inc. (US) | 2010-08-18 | — | — | EP | disclosed |
| WO-2009061453-A1 | SOLUBILIZED THIAZOLOPYRIDINES | SIRTRIS PHARMACEUTICALS, INC. (US) | 2009-05-14 | — | — | WO | disclosed |