Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.56 |
| ▸ | HTT | P42858 | 3/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | BLM | P54132 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2929687 | 1.00 | KDM4E (0.56) | KDM4EHTTPOLBBLMMEN1 | |
| SCHEMBL985553 | 0.82 | NPC1 (0.56) | KDM4EPOLBALDH1A1 | |
| SCHEMBL2906146 | 0.80 | ALDH1A1 (0.52) | KDM4EMEN1KMT2AALDH1A1TDP1 | |
| SCHEMBL985052 | 0.77 | KDM4E (0.44) | KDM4EHTTPOLBBLMMEN1 | |
| SCHEMBL4262285 | 0.76 | MCL1 (0.49) | — | |
| SCHEMBL984214 | 0.76 | ACKR3 (0.49) | — | |
| SCHEMBL1111239 | 0.76 | P2RY12 (0.52) | — | |
| SCHEMBL14204986 | 0.75 | KDM4E (0.61) | KDM4EHTTPOLBBLMMEN1 | |
| SCHEMBL2899930 | 0.75 | MCL1 (0.52) | KDM4EALDH1A1 | |
| SCHEMBL4271936 | 0.74 | NPC1 (0.55) | KDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2217606-A1 | SOLUBILIZED THIAZOLOPYRIDINES | Sirtris Pharmaceuticals, Inc. (US) | 2010-08-18 | — | — | EP | disclosed |
| WO-2009061453-A1 | SOLUBILIZED THIAZOLOPYRIDINES | SIRTRIS PHARMACEUTICALS, INC. (US) | 2009-05-14 | — | — | WO | disclosed |