Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 | Q9H244 | 11/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL985081 | 0.88 | PPARG (0.56) | P2RY12KDM4EALDH1A1 | |
| SCHEMBL2906146 | 0.88 | ALDH1A1 (0.52) | P2RY12KDM4EALDH1A1 | |
| SCHEMBL12814126 | 0.88 | KDM4E (0.47) | KDM4EALDH1A1 | |
| SCHEMBL983177 | 0.83 | P2RY12 (0.51) | P2RY12 | |
| SCHEMBL981734 | 0.80 | MAPT (0.48) | P2RY12KDM4EALDH1A1 | |
| SCHEMBL985553 | 0.75 | NPC1 (0.56) | KDM4EALDH1A1 | |
| SCHEMBL15763878 | 0.75 | KDM4E (0.55) | KDM4EALDH1A1 | |
| SCHEMBL9199244 | 0.74 | KCNH2 (0.63) | KDM4EALDH1A1 | |
| SCHEMBL984214 | 0.72 | ACKR3 (0.49) | P2RY12 | |
| SCHEMBL16724449 | 0.71 | P2RY12 (0.51) | P2RY12KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2217606-A1 | SOLUBILIZED THIAZOLOPYRIDINES | Sirtris Pharmaceuticals, Inc. (US) | 2010-08-18 | — | — | EP | disclosed |
| WO-2009061453-A1 | SOLUBILIZED THIAZOLOPYRIDINES | SIRTRIS PHARMACEUTICALS, INC. (US) | 2009-05-14 | — | — | WO | disclosed |