Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UGT1A1 | P22309 | 1/20 | 0.33 |
| ▸ | MAT2A | P31153 | 1/20 | 0.33 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.33 |
| ▸ | PDE9A | O76083 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.30 |
| ▸ | NPC1 | O15118 | 2/20 | 0.30 |
| ▸ | RAB9A | P51151 | 2/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | TDP2 | O95551 | 1/20 | 0.30 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | CASP3 | P42574 | 1/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
| ▸ | CASP7 | P55210 | 1/20 | 0.30 |
| ▸ | CASP9 | P55211 | 1/20 | 0.30 |
| ▸ | CASP6 | P55212 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | PIM1 | P11309 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30584032 | 1.00 | UGT1A1 (0.33) | UGT1A1MAT2ASLCO1B1PDE9AMEN1 | |
| SCHEMBL30584014 | 0.79 | MAT2A (0.41) | UGT1A1MAT2ASLCO1B1MEN1NPC1 | |
| SCHEMBL29062470 | 0.79 | MAT2A (0.41) | UGT1A1MAT2ASLCO1B1MEN1NPC1 | |
| SCHEMBL30584019 | 0.79 | MAT2A (0.41) | UGT1A1MAT2ASLCO1B1MEN1NPC1 | |
| SCHEMBL30584023 | 0.78 | UGT1A1 (0.33) | UGT1A1MAT2ASLCO1B1 | |
| SCHEMBL29062443 | 0.75 | PIM1 (0.36) | UGT1A1MAT2ASLCO1B1MEN1NPC1 | |
| SCHEMBL30719375 | 0.74 | PIM1 (0.40) | MEN1NPC1RAB9AKMT2AKDM4E | |
| SCHEMBL30584033 | 0.73 | MAPT (0.31) | MAPT | |
| SCHEMBL29062469 | 0.73 | MAPT (0.31) | MAPT | |
| SCHEMBL29062438 | 0.67 | MAT2A (0.43) | UGT1A1MAT2ASLCO1B1MEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117777134-A | Polycyclic compounds as MAT2A inhibitors | 艾立康药业股份有限公司 | 2024-03-29 | — | — | CN | disclosed |
| CN-116425751-B | Polycyclic compounds as MAT2A inhibitors | 艾立康药业股份有限公司 | 2024-01-23 | — | — | CN | disclosed |
| CN-116425751-A | Polycyclic compounds as MAT2A inhibitors | 艾立康药业股份有限公司 | 2023-07-14 | — | — | CN | disclosed |