SCHEMBL2906317

SCHEMBL2906317

c1csc2ccc3ccnc3c2c1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 4/20 0.43
MAPT P10636 3/20 0.40
HSD17B10 Q99714 2/20 0.40
KDM4E B2RXH2 5/20 0.39
SMN1; SMN2 Q16637 3/20 0.39
HTT P42858 3/20 0.39
CCR1 P32246 2/20 0.39
CCR5 P51681 2/20 0.39
CCR8 P51685 2/20 0.39
MMP2 P08253 2/20 0.39
ALOX15 P16050 2/20 0.39
TP53 P04637 2/20 0.39
HSP90AA1 P07900 2/20 0.39
TDP1 Q9NUW8 2/20 0.39
GMNN O75496 1/20 0.39
CYP3A4 P08684 1/20 0.39
CYP2D6 P10635 1/20 0.39
MMP9 P14780 1/20 0.39
TSHR P16473 1/20 0.39
NFKB1 P19838 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL58137 0.81 LMNA (0.54) LMNAMAPTKDM4ESMN1; SMN2HTT
Urea SCHEMBL17242046 0.74 PARP1 (0.47) LMNAMAPTHSD17B10KDM4ESMN1; SMN2
SCHEMBL7289957 0.70 HTR2C (0.33) LMNAMAPTKDM4ECYP2A6
SCHEMBL3194625 0.70 LMNA (0.55) LMNAMAPTHSD17B10KDM4ESMN1; SMN2
SCHEMBL2049452 0.66 HTR2C (0.35) LMNAMAPTKDM4EHTTTDP1
SCHEMBL10923588 0.65 LMNA (0.78) LMNAMAPTHSD17B10KDM4ESMN1; SMN2
SCHEMBL9533808 0.65 KDM4E (0.38) LMNAMAPTHSD17B10KDM4EHTT
SCHEMBL3281683 0.64 HTR2C (0.36) LMNAMAPTKDM4EHTTTDP1
SCHEMBL5004845 0.64 CCR1 (0.50) LMNAMAPTKDM4ESMN1; SMN2HTT
SCHEMBL3793682 0.64 CDK5 (0.54) LMNAMAPTKDM4ESMN1; SMN2HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 147 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-6287192-A None JP disclosed
US-20240238254-A1 PHARMACOLOGICAL INTERVENTION OF THE ARACHIDONIC ACID PATHWAY TO CURE AMYOTROPHIC LATERAL SCLEROSIS THE JOHNS HOPKINS UNIVERSITY (US) 2024-07-18 US disclosed
WO-2022251254-A1 PHARMACOLOGICAL INTERVENTION OF THE ARACHIDONIC ACID PATHWAY TO CURE AMYOTROPHIC LATERAL SCLEROSIS THE JOHNS HOPKINS UNIVERSITY (US) 2022-12-01 WO disclosed
CN-110054579-B Preparation method and application of 4- (1-H indole) phenol derivative 贵州省中国科学院天然产物化学重点实验室 2022-07-29 CN disclosed
CN-111606924-A Chiral thiopyranoindolophenylthiolsulfone derivatives and preparation method thereof 成都大学 2020-09-01 CN disclosed
US-7790723-B2 Thiazole derivatives as phosphodiesterase IV inhibitors MERCK PATENT GMBH (DE) 2010-09-07 US disclosed
EP-1343769-B1 BENZOYLPYRIDAZINES MERCK PATENT GMBH (DE) 2010-08-04 EP disclosed
EP-1511737-B1 ARYLOXIMES MERCK PATENT GMBH (DE) 2010-02-17 EP disclosed
EP-1509506-B1 PYRIDAZINE DERIVATIVES MERCK PATENT GMBH (DE) 2009-08-05 EP disclosed
US-7563790-B2 Pyridazine derivatives MERCK PATENT GMBH (DE) 2009-07-21 US disclosed
US-4056537-A CYCLIZATION, ACID CATALYST AYERST MCKENNA AND HARRISON LTD. (CA) 1977-11-01 US disclosed
US-4041169-A TREATING AND PREVENTING ULCERS AYERST MCKENNA AND HARRISON LTD. (CA) 1977-08-09 US disclosed
US-4041169-A TREATING AND PREVENTING ULCERS AYERST MCKENNA AND HARRISON LTD. (CA) 1977-08-09 US disclosed
US-4041169-A TREATING AND PREVENTING ULCERS AYERST MCKENNA AND HARRISON LTD. (CA) 1977-08-09 US disclosed
US-4003913-A ANTIDEPRESSANTS, ANTIULCER AGENTS AYERST MCKENNA AND HARRISON LTD. (CA) 1977-01-18 US disclosed
US-4003913-A ANTIDEPRESSANTS, ANTIULCER AGENTS AYERST MCKENNA AND HARRISON LTD. (CA) 1977-01-18 US disclosed
US-4003913-A ANTIDEPRESSANTS, ANTIULCER AGENTS AYERST MCKENNA AND HARRISON LTD. (CA) 1977-01-18 US disclosed
US-3880853-A Pyrano-and thiopyranoindole AYERST MCKENNA & HARRISON 1975-04-29 US disclosed
US-3880853-A Pyrano-and thiopyranoindole AYERST MCKENNA & HARRISON 1975-04-29 US disclosed
US-3852285-A PYRANO- AND THIOPYRANOINDOLE DERIVATIVES AYERST MCKENNA & HARRISON 1974-12-03 US disclosed