SCHEMBL29064016

SCHEMBL29064016

COc1cc(OC)cc(C2CNC2)c1

nearest known ligand 0.48

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.48
HTR2C P28335 4/20 0.44
CHRNB2 P17787 6/20 0.43
CHRNA4 P43681 6/20 0.43
CHRNB4 P30926 5/20 0.43
CHRNA3 P32297 5/20 0.43
CHRNA7 P36544 2/20 0.42
HTR2A P28223 2/20 0.42
ADRB1 P08588 1/20 0.41
CYP1A1 P04798 1/20 0.38
CYP1B1 Q16678 1/20 0.38
MAOA P21397 1/20 0.36
HTR2B P41595 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10401509 0.84 HTR2C (0.56) HTR2CHTR2AMAOAHTR2B
SCHEMBL11263002 0.83 HTR2A (0.53) HTR2CHTR2AHTR2B
SCHEMBL11264196 0.81 CYP2D6 (0.49) HTR2CHTR2AHTR2B
SCHEMBL22667384 0.80 HTR2C (0.70) HTR2CCHRNB2CHRNA4CHRNB4CHRNA3
Hydrochloric Acid SCHEMBL11269391 0.80 CYP2D6 (0.47) HTR2CHTR2AHTR2B
SCHEMBL1613815 0.79 ALDH1A1 (0.55) ALDH1A1HTR2CCYP1A1CYP1B1
SCHEMBL5584971 0.79 HTR2C (0.69) ALDH1A1HTR2CHTR2AADRB1MAOA
SCHEMBL15151146 0.78 MAOA (0.51) ALDH1A1CHRNB2CHRNA4CHRNB4CHRNA3
SCHEMBL12297790 0.77 HTR2C (0.50) ALDH1A1HTR2CCYP1A1CYP1B1
SCHEMBL12026078 0.76 ALDH1A1 (0.50) ALDH1A1HTR2CCHRNB2CHRNA4CHRNB4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116514806-A Biological inhibitor containing acrylketone, preparation method and application thereof 上海翰森生物医药科技有限公司 2023-08-01 CN disclosed