Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 14/20 | 0.47 |
| ▸ | THRA | P10827 | 14/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.43 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.43 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24407945 | 0.85 | THRB (0.59) | THRBTHRACYP2C9UGT1A1ABCG2 | |
| SCHEMBL29066225 | 0.85 | THRA (0.61) | THRBTHRACYP2C9UGT1A1ABCG2 | |
| SCHEMBL29066198 | 0.82 | THRB (0.54) | THRBTHRACYP2C9UGT1A1ABCG2 | |
| SCHEMBL29066229 | 0.81 | THRA (0.61) | THRBTHRACYP2C9UGT1A1ABCG2 | |
| SCHEMBL29632800 | 0.79 | THRA (0.65) | THRBTHRACYP2C9UGT1A1ABCG2 | |
| SCHEMBL29066193 | 0.77 | THRB (0.45) | THRBTHRACYP2C9UGT1A1ABCG2 | |
| SCHEMBL29066237 | 0.77 | THRB (0.42) | THRBTHRACYP2C9UGT1A1ABCG2 | |
| SCHEMBL29527306 | 0.77 | THRA (0.48) | THRBTHRACYP2C9UGT1A1ABCG2 | |
| SCHEMBL24407958 | 0.76 | THRB (0.59) | THRBTHRACYP2C9UGT1A1ABCG2 | |
| SCHEMBL29066187 | 0.75 | THRB (0.46) | THRBTHRACYP2C9UGT1A1ABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116710443-A | 2-pyridones as thyroid hormone receptor modulators | 阿利戈斯治疗公司 | 2023-09-05 | — | — | CN | disclosed |