Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | PAM | P19021 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | PLAU | P00749 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.41 |
| ▸ | USP5 | P45974 | 1/20 | 0.41 |
| ▸ | USP4 | Q13107 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1358287 | 0.83 | KDM4E (0.59) | MAPK1TDP1HTTSMN1; SMN2TSHR | |
| SCHEMBL11622076 | 0.82 | MAPK1 (0.52) | MAPK1TDP1HTTSMN1; SMN2TSHR | |
| SCHEMBL10573912 | 0.81 | MAPK1 (0.61) | MAPK1TDP1SMN1; SMN2TSHRL3MBTL1 | |
| SCHEMBL2940246 | 0.81 | KDM4E (0.49) | TDP1HTTTSHRL3MBTL1ALDH1A1 | |
| SCHEMBL12612133 | 0.81 | KDM4E (0.42) | TDP1HTTTSHRALDH1A1KDM4E | |
| SCHEMBL6847069 | 0.79 | MAPK1 (0.50) | MAPK1TDP1HTTSMN1; SMN2TSHR | |
| SCHEMBL27658575 | 0.78 | SLC6A3 (0.62) | MAPK1TDP1HTTSMN1; SMN2TSHR | |
| Hydrochloric Acid SCHEMBL8904401 | 0.78 | KDM4E (0.47) | TDP1HTTSMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL23249713 | 0.78 | KDM4E (0.44) | TDP1HTTTSHRALDH1A1KDM4E | |
| SCHEMBL27608335 | 0.77 | KDM4E (0.49) | MAPK1HTTSMN1; SMN2TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222682-A1 | IMIDAZO-THIAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS | Abbott Laboratories (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2009070516-A1 | IMIDAZO-THIAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2009-06-04 | — | — | WO | disclosed |