Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 4/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | GPX4 | P36969 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.32 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.32 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.32 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2906643 | 0.82 | CACNA2D1 (0.39) | SLC6A9POLBCYP3A4CYP3A5GPX4 | |
| SCHEMBL4711968 | 0.78 | CYP3A4 (0.42) | SLC6A9CYP3A4CYP3A5GPX4KDM4E | |
| SCHEMBL976065 | 0.77 | SLC6A9 (0.38) | SLC6A9GPX4MEN1KMT2AKDM4E | |
| Drinabant SCHEMBL684143 | 0.76 | CYP3A4 (0.36) | SLC6A9CYP3A4CYP3A5GPX4CACNA2D1 | |
| SCHEMBL2906510 | 0.75 | MAPT (0.38) | SLC6A9POLBCYP3A4CYP3A5OPRD1 | |
| SCHEMBL975245 | 0.74 | SLC6A9 (0.39) | SLC6A9CYP3A4CYP3A5GPX4CACNA2D1 | |
| SCHEMBL975170 | 0.74 | SLC6A9 (0.38) | SLC6A9CYP3A4CYP3A5MEN1KMT2A | |
| SCHEMBL977045 | 0.73 | CACNA2D1 (0.41) | SLC6A9CNR2MEN1KMT2AKDM4E | |
| SCHEMBL2909614 | 0.73 | CACNA2D1 (0.39) | SLC6A9POLBCYP3A4CYP3A5GPX4 | |
| SCHEMBL4927549 | 0.72 | GPR84 (0.37) | SLC6A9CYP3A4CYP3A5GPX4CACNA2D1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1263722-B1 | PHARMACEUTICAL COMPOSITIONS CONTAINING AZETIDINE DERIVATIVES, NOVEL AZETIDINE DERIVATIVES AND PREPARATION THEREOF | AVENTIS PHARMA SA (FR) | 2010-08-25 | — | — | EP | claimed |
| EP-1328269-B1 | ASSOCIATION OF A CB1 RECEPTOR ANTAGONIST AND SIBUTRAMIN FOR TREATING OBESITY | AVENTIS PHARMA SA (FR) | 2004-05-26 | — | — | EP | claimed |