Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | GAPDH | P04406 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30421543 | 0.86 | SMN1; SMN2 (0.57) | SMN1; SMN2MAPTRAB9ANPC1MEN1 | |
| SCHEMBL29577697 | 0.85 | RAB9A (0.57) | SMN1; SMN2MAPTRAB9ANPC1MEN1 | |
| SCHEMBL25567547 | 0.81 | HPGD (0.61) | SMN1; SMN2RAB9ANPC1MEN1KMT2A | |
| SCHEMBL1888991 | 0.77 | MAPT (0.69) | SMN1; SMN2MAPTRAB9ANPC1MEN1 | |
| SCHEMBL1430419 | 0.72 | MAPT (0.67) | SMN1; SMN2MAPTRAB9ANPC1MEN1 | |
| SCHEMBL22462220 | 0.71 | MAPT (0.61) | SMN1; SMN2MAPTRAB9ANPC1MEN1 | |
| SCHEMBL5803752 | 0.71 | MAPT (0.65) | SMN1; SMN2MAPTRAB9ANPC1MEN1 | |
| SCHEMBL172042 | 0.71 | MAPT (0.65) | SMN1; SMN2MAPTRAB9ANPC1MEN1 | |
| SCHEMBL171882 | 0.71 | MAPT (0.70) | SMN1; SMN2MAPTRAB9ANPC1MEN1 | |
| SCHEMBL15144367 | 0.70 | LMNA (0.52) | SMN1; SMN2MAPTRAB9ANPC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116284043-B | Tricyclic compound and medical application thereof | 中国科学院上海药物研究所 | 2024-06-11 | — | — | CN | disclosed |
| CN-116284043-A | Tricyclic compound and medical application thereof | 中国科学院上海药物研究所 | 2023-06-23 | — | — | CN | disclosed |