Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Tetrahydrofuran. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.35 |
| ▸ | NPC1 | O15118 | 4/20 | 0.33 |
| ▸ | RAB9A | P51151 | 4/20 | 0.33 |
| ▸ | TP53 | P04637 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | ICMT | O60725 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
| ▸ | PRKDC | P78527 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL27529818 | 0.83 | — | — | |
| Tetrahydrofuran SCHEMBL27927339 | 0.78 | HTT (0.40) | HTTALDH1A1NPC1RAB9ATP53 | |
| Hydrochloric Acid SCHEMBL27546808 | 0.78 | — | — | |
| Iodide SCHEMBL27567051 | 0.78 | — | — | |
| Tetrahydrofuran SCHEMBL7246325 | 0.74 | HTT (0.40) | HTTALDH1A1NPC1RAB9ATP53 | |
| Tetrahydrofuran SCHEMBL27873625 | 0.74 | HTT (0.40) | HTTALDH1A1NPC1RAB9ATP53 | |
| Tetrahydrofuran SCHEMBL27873622 | 0.72 | HTT (0.42) | HTTALDH1A1MAPTHPGDKDM4E | |
| Tetrahydrofuran SCHEMBL27479339 | 0.70 | ALDH1A1 (0.40) | HTTALDH1A1SMN1; SMN2MAPTKMT2A | |
| Ether SCHEMBL27526903 | 0.68 | DPP4 (0.41) | ALDH1A1NPC1RAB9ASMN1; SMN2MAPT | |
| Tetrahydrofuran SCHEMBL29120088 | 0.67 | ALDH1A1 (0.33) | ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116694161-A | Acrylic polyurethane weather-resistant environment-friendly floor paint and preparation process thereof | 宁波宣威彩色世界涂料有限公司 | 2023-09-05 | — | — | CN | claimed |
| CN-116694161-A | Acrylic polyurethane weather-resistant environment-friendly floor paint and preparation process thereof | 宁波宣威彩色世界涂料有限公司 | 2023-09-05 | — | — | CN | disclosed |