Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 4/20 | 0.45 |
| ▸ | GSK3A | P49840 | 3/20 | 0.45 |
| ▸ | CDK1 | P06493 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.43 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 5/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.41 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2903991 | 0.89 | POLB (0.56) | POLBGSK3BGSK3ACDK1HTT | |
| SCHEMBL2912637 | 0.85 | POLB (0.47) | POLBGSK3BGSK3ACDK1HTT | |
| SCHEMBL2904807 | 0.84 | GSK3B (0.45) | GSK3BGSK3ACDK1SMN1; SMN2CCNB2 | |
| SCHEMBL2904684 | 0.84 | GSK3B (0.47) | POLBGSK3BGSK3ACDK1HTT | |
| SCHEMBL2910561 | 0.84 | GSK3B (0.51) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL2910255 | 0.82 | POLB (0.52) | POLBGSK3BGSK3ACDK1HTT | |
| SCHEMBL2910463 | 0.82 | POLB (0.52) | POLBGSK3BGSK3ACDK1HTT | |
| SCHEMBL2909753 | 0.81 | HPGD (0.47) | POLBGSK3BGSK3ACDK1HTT | |
| SCHEMBL2911856 | 0.81 | GSK3B (0.52) | GSK3BGSK3ACDK1SMN1; SMN2CCNB2 | |
| SCHEMBL2904255 | 0.81 | GSK3B (0.47) | POLBGSK3BGSK3ACDK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537099-B1 | PYRROLE BASED INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | NOVARTIS VACCINES & DIAGNOSTIC (US) | 2010-08-11 | — | — | EP | disclosed |