Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | JAK1 | P23458 | 1/20 | 0.48 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.42 |
| ▸ | TACR1 | P25103 | 2/20 | 0.41 |
| ▸ | CETP | P11597 | 6/20 | 0.41 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.41 |
| ▸ | UBE2M | P61081 | 3/20 | 0.40 |
| ▸ | DCUN1D1 | Q96GG9 | 3/20 | 0.40 |
| ▸ | GHSR | Q92847 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29069970 | 1.00 | JAK2 (0.48) | JAK2JAK1GPR119TACR1CETP | |
| SCHEMBL20920379 | 1.00 | JAK2 (0.48) | JAK2JAK1GPR119TACR1CETP | |
| SCHEMBL25487544 | 0.88 | JAK2 (0.49) | JAK2JAK1GPR119TACR1AGTR2 | |
| SCHEMBL29069990 | 0.87 | AGTR2 (0.46) | TACR1AGTR2UBE2MDCUN1D1ALDH1A1 | |
| SCHEMBL20567316 | 0.87 | AGTR2 (0.46) | TACR1AGTR2UBE2MDCUN1D1ALDH1A1 | |
| SCHEMBL29069991 | 0.87 | AGTR2 (0.46) | TACR1AGTR2UBE2MDCUN1D1ALDH1A1 | |
| SCHEMBL20566782 | 0.87 | AGTR2 (0.46) | TACR1AGTR2UBE2MDCUN1D1MEN1 | |
| SCHEMBL20920388 | 0.81 | MGLL (0.42) | JAK2JAK1GPR119SMN1; SMN2 | |
| SCHEMBL30218719 | 0.81 | MGLL (0.42) | JAK2JAK1GPR119SMN1; SMN2 | |
| SCHEMBL20567033 | 0.77 | MGLL (0.62) | TACR1AGTR2UBE2MDCUN1D1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116473965-A | Pyrazole MAGL inhibitors | H.隆德贝克有限公司 | 2023-07-25 | — | — | CN | disclosed |
| CN-110678456-B | Pyrazole MAGL inhibitors | H.隆德贝克有限公司 | 2023-05-02 | — | — | CN | disclosed |