Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.60 |
| ▸ | TSHR | P16473 | 4/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL942807 | 0.87 | TSHR (0.54) | HTTTSHRGAASMN1; SMN2ALDH1A1 | |
| SCHEMBL20927488 | 0.86 | TSHR (0.67) | HTTTSHRGAASMN1; SMN2ALDH1A1 | |
| SCHEMBL30837754 | 0.86 | TSHR (0.67) | HTTTSHRGAASMN1; SMN2ALDH1A1 | |
| SCHEMBL7019067 | 0.85 | APEX1 (0.47) | HTTTSHRRAB9AGAASMN1; SMN2 | |
| SCHEMBL4004421 | 0.85 | APEX1 (0.60) | APEX1 | |
| SCHEMBL2351986 | 0.81 | TSHR (0.47) | HTTTSHRGAASMN1; SMN2ALDH1A1 | |
| SCHEMBL4887579 | 0.79 | CYP1A2 (0.69) | HTTTSHRALOX15GAASMN1; SMN2 | |
| SCHEMBL1949836 | 0.79 | HTT (0.57) | HTTTSHRGAASMN1; SMN2ALDH1A1 | |
| SCHEMBL28827968 | 0.79 | HPGD (0.62) | HTTRAB9AGAASMN1; SMN2LMNA | |
| SCHEMBL2089415 | 0.78 | HTT (0.53) | HTTTSHRALDH1A1LMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951692-B1 | OXAZOLE AND THIAZOLE PPAR MODULATOR | IRM LLC (BM) | 2010-08-18 | — | — | EP | disclosed |
| US-20100048453-A1 | OXAZOLE AND THIAZOLE PPAR MODULATOR | IRM LLC (BM) | 2010-02-25 | — | — | US | disclosed |
| US-20100048453-A1 | OXAZOLE AND THIAZOLE PPAR MODULATOR | IRM LLC (BM) | 2010-02-25 | — | — | US | disclosed |
| US-20100048453-A1 | OXAZOLE AND THIAZOLE PPAR MODULATOR | IRM LLC (BM) | 2010-02-25 | — | — | US | disclosed |
| US-20090088368-A1 | COMPOSITIONS COMPRISING THEM AS PPAR MODULATORS | IRM LLC (BM) | 2009-04-02 | — | — | US | disclosed |
| US-20090088368-A1 | COMPOSITIONS COMPRISING THEM AS PPAR MODULATORS | IRM LLC (BM) | 2009-04-02 | — | — | US | disclosed |
| EP-1979360-A1 | COMPOUNDS AND COMPOSITIONS AS PPAR MODULATORS | IRM LLC (BM) | 2008-10-15 | — | — | EP | disclosed |
| EP-1951692-A1 | OXAZOLE AND THIAZOLE PPAR MODULATOR | IRM LLC (BM) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007089667-A1 | COMPOUNDS AND COMPOSITIONS AS PPAR MODULATORS | IRM LLC (BM) | 2007-08-09 | — | — | WO | disclosed |
| WO-2007056496-A1 | OXAZOLE AND THIAZOLE PPAR MODULATOR | IRM LLC (BM) | 2007-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048453-A1 | OXAZOLE AND THIAZOLE PPAR MODULATOR | PPARD, PPARG, PPARA | HTT 2677/4885TSHR 343/4885RAB9A 4182/4885 |
| US-20090088368-A1 | COMPOSITIONS COMPRISING THEM AS PPAR MODULATORS | PPARG, PPARA, PPARD | HTT 1762/4885TSHR 549/4885RAB9A 2956/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.