Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.35 |
| ▸ | MET | P08581 | 2/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MYC | P01106 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2913013 | 0.90 | ALDH1A1 (0.33) | ALDH1A1METAXLHTTHPGD | |
| SCHEMBL2913339 | 0.81 | ALDH1A1 (0.34) | ALDH1A1HPGDCYP3A4KDM4EMAPT | |
| SCHEMBL2913854 | 0.80 | — | — | |
| SCHEMBL1530207 | 0.77 | CRBN (0.36) | ALDH1A1HPGDCYP3A4SMN1; SMN2KDM4E | |
| SCHEMBL1530145 | 0.73 | CRBN (0.52) | ALDH1A1METHPGDKDM4EMAPT | |
| SCHEMBL1530176 | 0.71 | ALDH1A1 (0.31) | ALDH1A1HPGD | |
| SCHEMBL2915235 | 0.70 | RARG (0.34) | ALDH1A1HPGDKDM4EMAPTGAA | |
| SCHEMBL2908263 | 0.70 | CYP3A4 (0.57) | CYP3A4 | |
| SCHEMBL2907825 | 0.70 | ALDH1A1 (0.34) | ALDH1A1HTTHPGDSMN1; SMN2KDM4E | |
| SCHEMBL1530199 | 0.70 | KDM4E (0.45) | ALDH1A1HPGDKDM4EKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222646-A1 | URACIL OR THYMINE DERIVATIVE FOR TREATING HEPATITIS C | Abbott Laboratories (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2009039127-A1 | URACIL OR THYMINE DERIVATIVE FOR TREATING HEPATITIS C | ABBOTT LABORATORIES (US) | 2009-03-26 | — | — | WO | disclosed |