Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 4/20 | 0.35 |
| ▸ | RAB9A | P51151 | 4/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | NPM1 | P06748 | 1/20 | 0.34 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11890643 | 0.87 | TLR8 (0.44) | TLR8BACE1NPC1RAB9AHTT | |
| SCHEMBL21810482 | 0.83 | TLR8 (0.36) | TLR8BACE1NPC1RAB9AHTT | |
| SCHEMBL27006138 | 0.81 | HDAC8 (0.36) | TLR8BACE1NPC1RAB9AHTT | |
| SCHEMBL27007121 | 0.81 | TLR8 (0.41) | TLR8BACE1NPC1RAB9AHTT | |
| SCHEMBL25339190 | 0.80 | TLR8 (0.40) | TLR8BACE1NPC1RAB9AHTT | |
| SCHEMBL20135108 | 0.80 | TLR8 (0.57) | TLR8HTT | |
| SCHEMBL30122249 | 0.80 | IRAK4 (0.41) | TLR8HTTMAPTALDH1A1 | |
| SCHEMBL25338343 | 0.79 | TLR8 (0.44) | TLR8BACE1NPC1RAB9AHTT | |
| Hydrochloric Acid SCHEMBL30508248 | 0.79 | TLR8 (0.56) | TLR8HTT | |
| SCHEMBL25911938 | 0.79 | TLR8 (0.44) | TLR8NPC1RAB9AHTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116867758-A | IRAK degradation agents and uses thereof | 凯麦拉医疗公司 | 2023-10-10 | — | — | CN | disclosed |
| CN-116669722-A | Interleukin-1 receptor-related kinase (IRAK) degradants and uses thereof | 凯麦拉医疗公司 | 2023-08-29 | — | — | CN | disclosed |