Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 7/20 | 0.66 |
| ▸ | GSK3B | P49841 | 7/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.62 |
| ▸ | MEN1 | O00255 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | GAA | P10253 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | THRB | P10828 | 2/20 | 0.62 |
| ▸ | HTT | P42858 | 2/20 | 0.62 |
| ▸ | RECQL | P46063 | 2/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4399435 | 0.80 | GSK3A (0.71) | GSK3AGSK3BKMT2AMEN1ALDH1A1 | |
| SCHEMBL20339366 | 0.80 | GSK3A (0.71) | GSK3AGSK3BKMT2AMEN1ALDH1A1 | |
| SCHEMBL20339372 | 0.77 | GSK3A (1.00) | GSK3AGSK3BKMT2AMEN1ALDH1A1 | |
| SCHEMBL20339824 | 0.77 | GSK3A (0.66) | GSK3AGSK3BKMT2AMEN1ALDH1A1 | |
| SCHEMBL5468543 | 0.77 | GSK3A (0.66) | GSK3AGSK3BKMT2AMEN1ALDH1A1 | |
| SCHEMBL6793399 | 0.77 | ALDH1A1 (1.00) | GSK3AGSK3BKMT2AMEN1ALDH1A1 | |
| SCHEMBL28555685 | 0.76 | ALDH1A1 (0.56) | ALDH1A1POLBCYP19A1ADRA1DADRA1A | |
| SCHEMBL15863164 | 0.75 | GSK3A (0.64) | GSK3AGSK3BKMT2AMEN1ALDH1A1 | |
| SCHEMBL5464121 | 0.74 | GSK3A (0.76) | GSK3AGSK3BKMT2AMEN1ALDH1A1 | |
| SCHEMBL5464124 | 0.74 | GSK3A (0.76) | GSK3AGSK3BKMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110065715-A1 | Nogo Receptor Binding Small Molecules to Promote Axonal Growth | YALE UNIVERSITY (US) | 2011-03-17 | — | — | US | claimed |
| EP-2220499-A2 | NOGO RECEPTOR BINDING SMALL MOLECULES TO PROMOTE AXONAL GROWTH | Yale University (US) | 2010-08-25 | — | — | EP | claimed |
| WO-2009073141-A2 | NOGO RECEPTOR BINDING SMALL MOLECULES TO PROMOTE AXONAL GROWTH | STRITTMATTER STEPHEN M (US) | 2009-06-11 | — | — | WO | claimed |
| US-20110065715-A1 | Nogo Receptor Binding Small Molecules to Promote Axonal Growth | YALE UNIVERSITY (US) | 2011-03-17 | — | — | US | disclosed |
| US-20110065715-A1 | Nogo Receptor Binding Small Molecules to Promote Axonal Growth | YALE UNIVERSITY (US) | 2011-03-17 | — | — | US | disclosed |
| US-20110065715-A1 | Nogo Receptor Binding Small Molecules to Promote Axonal Growth | YALE UNIVERSITY (US) | 2011-03-17 | — | — | US | disclosed |
| EP-2220499-A2 | NOGO RECEPTOR BINDING SMALL MOLECULES TO PROMOTE AXONAL GROWTH | Yale University (US) | 2010-08-25 | — | — | EP | disclosed |
| WO-2009073141-A2 | NOGO RECEPTOR BINDING SMALL MOLECULES TO PROMOTE AXONAL GROWTH | STRITTMATTER STEPHEN M (US) | 2009-06-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110065715-A1 | Nogo Receptor Binding Small Molecules to Promote Axonal Growth | NGFR, GAP43, BDNF | GSK3A 1154/4885GSK3B 970/4885KMT2A 4600/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.