Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 15/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.45 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.40 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10602491 | 0.71 | TSHR (0.59) | SMN1; SMN2 | |
| SCHEMBL15759221 | 0.69 | SRD5A1 (0.40) | KDM2BGRIN2B | |
| SCHEMBL15759196 | 0.69 | SRD5A1 (0.40) | KDM2BGRIN2B | |
| SCHEMBL13368428 | 0.69 | KDM2B (0.39) | HRH3KDM2BGRIN2B | |
| SCHEMBL13368494 | 0.69 | KDM2B (0.39) | HRH3KDM2BGRIN2B | |
| SCHEMBL2060941 | 0.68 | CCR4 (0.35) | KDM2BDPP4DPP8DPP9 | |
| SCHEMBL2908455 | 0.67 | DRD2 (0.36) | KDM2BDPP4DPP8DPP9 | |
| SCHEMBL4128738 | 0.66 | USP30 (0.36) | HRH3KDM2B | |
| SCHEMBL4136604 | 0.66 | KDM2B (0.42) | HRH3KDM2B | |
| SCHEMBL10203272 | 0.66 | MEN1 (0.40) | HRH3KDM2BGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222647-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | Cephalon, Inc. (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2008051547-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2008-05-02 | — | — | WO | disclosed |