Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | CCR4 | P51679 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.34 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.32 |
| ▸ | KCNA5 | P22460 | 5/20 | 0.31 |
| ▸ | SCN5A | Q14524 | 5/20 | 0.31 |
| ▸ | KCND2 | Q9NZV8 | 5/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2913227 | 0.82 | DRD2 (0.40) | DRD2HTR2A | |
| SCHEMBL2479144 | 0.79 | DRD1 (0.35) | DRD2HTR2ADRD1SLC6A4BRD4 | |
| SCHEMBL2915586 | 0.79 | DRD1 (0.35) | DRD2HTR2ADRD1SLC6A4BRD4 | |
| SCHEMBL17729306 | 0.72 | IDO1 (0.42) | DRD2HTR2ADRD1SLC6A4 | |
| SCHEMBL2060941 | 0.70 | CCR4 (0.35) | CCR4DPP4DPP8DPP9KDM2B | |
| SCHEMBL2908453 | 0.67 | HRH3 (0.45) | DPP4DPP8DPP9KDM2B | |
| SCHEMBL4294921 | 0.65 | USP30 (0.41) | KCNH2 | |
| SCHEMBL24717540 | 0.65 | HRH3 (0.34) | CCR4DPP4DPP8DPP9KDM2B | |
| SCHEMBL24717539 | 0.65 | HRH3 (0.34) | CCR4DPP4DPP8DPP9KDM2B | |
| SCHEMBL7008801 | 0.64 | CHRNA7 (0.53) | BRD4ATAD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222647-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | Cephalon, Inc. (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2008051547-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2008-05-02 | — | — | WO | disclosed |