Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | HTT | P42858 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | CCR2 | P41597 | 1/20 | 0.37 |
| ▸ | NMT1 | P30419 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2907371 | 0.87 | MAPT (0.45) | GAAMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL2901726 | 0.85 | MAPT (0.46) | GAAMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL2907789 | 0.83 | GLO1 (0.43) | GAAMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL2901736 | 0.83 | L3MBTL1 (0.40) | GAAMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL2902288 | 0.82 | HTT (0.40) | GAAMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL2904287 | 0.82 | L3MBTL1 (0.48) | GAAMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL2907027 | 0.81 | NFKBIA (0.46) | GAAMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL2245273 | 0.79 | BRD4 (0.41) | GAAMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL2907292 | 0.78 | NPC1 (0.42) | GAAMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL2906805 | 0.78 | NPC1 (0.46) | GAAMEN1KMT2AALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2076495-B1 | QUINOLINE DERIVATIVES WITH 5-HT-BINDING PROPERTIES | HOFFMANN LA ROCHE (CH) | 2010-08-18 | — | — | EP | claimed |