Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | CTSD | P07339 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | RORC | P51449 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2871282 | 0.88 | CTSD (0.59) | HDAC1HDAC6HDAC3HDAC2CTSD | |
| SCHEMBL29087387 | 0.87 | RORC (0.54) | HDAC1HDAC6HDAC3HDAC2CTSD | |
| SCHEMBL30702488 | 0.82 | RORC (0.45) | HDAC1HDAC6HDAC3HDAC2CTSD | |
| SCHEMBL30702551 | 0.82 | HDAC1 (0.43) | HDAC1HDAC6HDAC3HDAC2OPRD1 | |
| SCHEMBL29087369 | 0.80 | RORC (0.45) | HDAC1HDAC6HDAC3HDAC2CTSD | |
| SCHEMBL27225766 | 0.78 | HDAC1 (0.50) | HDAC1HDAC6HDAC3HDAC2OPRD1 | |
| SCHEMBL31559321 | 0.77 | HDAC1 (0.42) | HDAC1HDAC6HDAC3HDAC2OPRD1 | |
| SCHEMBL3024456 | 0.77 | MEN1 (0.51) | HDAC1HDAC6HDAC3HDAC2OPRD1 | |
| SCHEMBL3024328 | 0.76 | SMN1; SMN2 (0.50) | HDAC1HDAC6HDAC3HDAC2OPRD1 | |
| SCHEMBL17188016 | 0.76 | HDAC3 (0.50) | HDAC1HDAC6HDAC3HDAC2CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4288414-A1 | SUBSTITUTED CYCLIC MODULATORS OF PROTEIN PHOSPHATASE 2A (PP2A) AND METHODS USING SAME | Rappta Therapeutics Oy (FI) | 2023-12-13 | — | — | EP | disclosed |
| CN-116806217-A | Substituted cyclic modulators of protein phosphatase 2A (PP 2A) and methods of use thereof | 拉帕塔疗法公司 | 2023-09-26 | — | — | CN | disclosed |
| WO-2022167867-A1 | SUBSTITUTED CYCLIC MODULATORS OF PROTEIN PHOSPHATASE 2A (PP2A) AND METHODS USING SAME | RAPPTA THERAPEUTICS OY (FI) | 2022-08-11 | — | — | WO | disclosed |